Evaluation of Cytotoxicity and Mutagenicity of Wastewater from Istanbul: Data from Hospitals and Advanced Wastewater Treatment Plant

• Published in: Bulletin of environmental contamination and toxicology Vol. 104; no. 6; pp. 852 - 857
• Main Authors: Cevik, Mehtap, Dartan, Guler, Ulker, Melike, Bezci, Kıvanç, Deliorman, Gokce, Cagatay, Penbe, Lacin, Tunc, Cinel, Ismail Hakkı, Aksu, Burak, Keskin, Yasar, Can, Zehra Semra, Yurdun, Turkan, Susleyici, Belgin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2020; Springer Nature B.V
• Subjects: Advanced wastewater treatment; Aquatic environment; Aquatic Pollution; Assaying; Cytotoxicity; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Fibroblasts; Hepatocytes; Hospitals; L-Lactate dehydrogenase; Lactate dehydrogenase; Lactic acid; Mutagenicity; Pollution; Sewage disposal; Soil Science & Conservation; Toxicity; Waste Water Technology; Wastewater treatment; Wastewater treatment plants; Water Management; Water Pollution Control; Water treatment; Istanbul Turkey; Turkey; Cytotoxicity; Wastewater treatment plant; Mutagenicity; Hospital wastewater; Wastewater
• ISSN: 0007-4861; 1432-0800
• DOI: 10.1007/s00128-020-02853-6

Wastewater (WW) carry considerable amount of chemicals that could have mutagenic or cytotoxic effect from hospital discharges to aquatic environment. Our objective was to determinate the possible mutagenic and toxic effects of hospital originated WWs and effectiveness of the wastewater treatment plants (WTP) functions. In the study the mutagenic and cytotoxic potential of three hospitals and influent/effluent of a treatment plant WW collected in Istanbul and was examined using AMES, XTT, and lactate dehydrogenase (LDH) assays. Mutagenic effects were detected at both hospital discharges and advanced biological wastewater plant. We observed no cytotoxic effect in fibroblasts for LDH and XTT assays whereas high cytotoxicity for all samples was found in hepatocytes by XTT assay. According to the results even if advanced technology is used for treatment of WW, mutagenic and cytotoxic effects still remain, and the present technologies need to be further improved.