Clinical Impact of Extranodal Metabolic Tumor Volume in 240 Diffuse Large B cell Lymphoma Patients with Extranodal Involvement
The present study is to investigate whether extranodal (EN) metabolic tumor volume (MTV) would have a specific clinical meaning for survival in EN diffuse large B cell lymphoma (DLBCL) patients. Two hundred forty DLBCL patients with EN involvement received 18F-fluorodeoxygenase (FDG) positron emissi...
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Published in | Annals of hematology Vol. 100; no. 5; pp. 1221 - 1229 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.05.2021
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | The present study is to investigate whether extranodal (EN) metabolic tumor volume (MTV) would have a specific clinical meaning for survival in EN diffuse large B cell lymphoma (DLBCL) patients. Two hundred forty DLBCL patients with EN involvement received 18F-fluorodeoxygenase (FDG) positron emission tomography/computed tomography (PET/CT) were enrolled. Survival analysis revealed that low EN MTV (PFS [progression-free survival], HR = 0.278, 95% CI = 0.127–0.807,
p
= 0.001; OS [overall survival], HR = 0.320, 95% CI = 0.145–0.703,
p
= 0.003), low total MTV (PFS, HR = 0.194, 95% CI = 0.085–0.445,
p
< 0.001; OS, HR = 0.213, 95% CI = 0.092–0.491,
p
< 0.007), and high National Cancer Center Network-International Prognostic Index score (PFS, HR = 3.152, 95% CI = 1.732–5.734,
p
< 0.001; OS, HR = 2.457, 95% CI = 1.363–4.430,
p
= 0.003) were independently associated with survivals in the patients. Our data showed that EN MTV is a useful and novel prognostic parameter for predicting survival in DLBCL patients with EN involvement. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0939-5555 1432-0584 |
DOI: | 10.1007/s00277-021-04498-9 |