3D bioprinting and its in vivo applications

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Vol. 106; no. 1; pp. 444 - 459
• Main Authors: Hong, Nhayoung, Yang, Gi-Hoon, Lee, JaeHwan, Kim, GeunHyung
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2018
• Subjects: Animals; Biocompatibility; Bioengineering; Biomaterials; Biomedical materials; Biomedical Research - instrumentation; Biomedical Research - methods; Bioprinting - instrumentation; Bioprinting - methods; Drug delivery; Drug delivery systems; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; Fabrication; Humans; Materials research; Materials science; Organs; Printing; Printing, Three-Dimensional - instrumentation; Technology; Three dimensional printing; Tissues; Toxicology; Vascularization; clinical application; tissue engineering; 3D bioprinting
• ISSN: 1552-4973; 1552-4981
• DOI: 10.1002/jbm.b.33826

The purpose of 3D bioprinting technology is to design and create functional 3D tissues or organs in situ for in vivo applications. 3D cell-printing, or additive biomanufacturing, allows the selection of biomaterials and cells (bioink), and the fabrication of cell-laden structures in high resolution. 3D cell-printed structures have also been used for applications such as research models, drug delivery and discovery, and toxicology. Recently, numerous attempts have been made to fabricate tissues and organs by using various 3D printing techniques. However, challenges such as vascularization are yet to be solved. This article reviews the most commonly used 3D cell-printing techniques with their advantages and drawbacks. Furthermore, up-to-date achievements of 3D bioprinting in in vivo applications are introduced, and prospects for the future of 3D cell-printing technology are discussed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 444-459, 2018.