Systemic corticosteroids could be used as bridge treatment in children with obstructive sleep apnea syndrome waiting for surgery

• Published in: Sleep & breathing Vol. 26; no. 2; pp. 879 - 885
• Main Authors: Evangelisti, M., Barreto, M., Di Nardo, G., Del Pozzo, M., Parisi, P., Villa, Maria Pia
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2022; Springer Nature B.V
• Subjects: Anti-inflammatory agents; Apnea; Beclomethasone - therapeutic use; Betamethasone; Child; Child, Preschool; Children; Corticosteroids; Cytokines; Dentistry; Epilepsy; Humans; Hypertrophy; Inflammation; Internal Medicine; Medicine; Medicine & Public Health; Metabolic disorders; Neurology; Otorhinolaryngology; Pediatrics; Pediatrics • Original Article; Pneumology/Respiratory System; Polysomnography; Sleep; Sleep apnea; Sleep Apnea, Obstructive - diagnosis; Sleep disorders; Steroids; Surgery; Treatment; Corticosteroids; Obstructive sleep apnea; Sleep disoredered breathing
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-021-02436-7

Purpose Local and systemic inflammatory markers and pro-inflammatory cytokines are increased in children with obstructive sleep apnea syndrome (OSAS). Therefore, systemic or topical anti-inflammatory agents are used to treat this syndrome. We evaluated the treatment with systemic corticosteroids in children with severe OSAS and adenotonsillar hypertrophy before surgery. Methods This was an unblinded open label study. Children with severe OSAS (diagnosed through polysomnography, obstructive apnea–hypopnea index [AHI] > 10 eV/h) were recruited. Exclusion criteria included age < 3 years, history of acute or chronic cardiorespiratory or neuromuscular or metabolic disease; major craniofacial abnormalities; and chromosomal syndromes and epilepsy. Computer-generated random numbers were used for simple randomization of subjects. All children were treated with intranasal beclomethasone spray, and 15 children additionally received oral betamethasone and 0.1 mg/kg per day for 7 days. Sleep clinical record (SCR) and pulsoximetry were performed before and after 7 days in all children. Results Among 28 children with severe OSAS mean age was 4.5 ± 1.8 years, AHI 20.4 ± 1.8 eV/h). In children treated with intranasal and oral corticosteroids, mean (95.3 ± 1.1 vs 97.0 ± 0.8%, p  = 0.0001) and minimum oxygen saturation (78.8 ± 6.3 vs 89.2 ± 4.2, p  = 0.001) improved, and the SCR score (12.6 ± 1.2 vs 8.3 ± 1.1, p  = 0.0001) was reduced. Children treated only with intranasal beclomethasone spray showed no differences in outcome measures before and after treatments. When we considered the oximetry measures, after corticosteroid treatment, we obtained statistical differences between the 2 groups ( p  < 0.01). Conclusions These results seem to suggest that a short course of oral betamethasone could be useful to treat children with severe OSAS and adenotonsillar hypertrophy waiting for surgery.