EQ-5D-5L is More Responsive than EQ-5D-3L to Treatment Benefit of Cataract Surgery

• Published in: The patient : patient-centered outcomes research Vol. 12; no. 4; pp. 383 - 392
• Main Authors: Gandhi, Mihir, Ang, Marcus, Teo, Kelvin, Wong, Chee Wai, Wei, Yvonne Chung-Hsi, Tan, Rachel Lee-Yin, Janssen, Mathieu F., Luo, Nan
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2019; Springer Nature B.V
• Subjects: Aged; Algorithms; Cataract Extraction - statistics & numerical data; Cataracts; Cost-Benefit Analysis - methods; Diabetic retinopathy; Eye surgery; Female; Health Administration; Health Economics; Health Status; Humans; Interviews; Interviews as Topic; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Middle Aged; Original Research Article; Patient Preference; Pharmacoeconomics and Health Outcomes; Prospective Studies; Psychometrics; Public Health; Quality of Life; Quality of Life Research; Questionnaires; Reproducibility of Results; Singapore; Socioeconomic Factors; Statistics; Surveys and Questionnaires - standards; Trends; Visual Acuity; Singapore; England; Canada; United Kingdom > UK
• ISSN: 1178-1653; 1178-1661
• DOI: 10.1007/s40271-018-00354-7

Background It is not clear whether 5-level EQ-5D (EQ-5D-5L) utilities based on recently developed value sets are more responsive than 3-level EQ-5D (EQ-5D-3L) utilities. Objectives The study aims were to compare (1) the responsiveness of EQ-5D-5L and EQ-5D-3L utilities and (2) the responsiveness of these utilities with the Short Form–6 Dimension (SF-6D) and Health Utilities Index Mark 3 (HUI3) utilities to the treatment benefit of cataract surgery. Methods A total of 148 patients were interviewed before and after their cataract surgery using EQ-5D-3L, EQ-5D-5L, SF-6D, and HUI3. Responsiveness was assessed for all measures using the mean change (post-treatment—pre-treatment), standardized effect size (SES), standardized response mean (SRM), and F -statistic. Results Using the Singapore value sets, mean change for EQ-5D-3L and EQ-5D-5L utilities was 0.016 and 0.028, SES was 0.097 and 0.199; SRM was 0.091 and 0.196; and F -statistic was 1.2 and 5.7, respectively. Similar trends were observed using the UK/England EQ-5D value sets, although the magnitude was slightly smaller. The mean change, SES, SRM and F -statistics for SF-6D (UK value set) were 0.020, 0.234, 0.249, and 9.2, respectively. The values of mean change, SES, SRM and F -statistics for HUI3 (Canada value set) were 0.080, 0.472, 0.474, and 33.3, respectively. Conclusions The EQ-5D-5L utilities tend to be more responsive than the EQ-5D-3L utilities to treatment benefits of cataract surgery. The HUI3 utilities are more responsive than both the EQ-5D-5L and SF-6D, and SF-6D utilities may be slightly more responsive than the EQ-5D-5L for assessing patients undergoing cataract surgery.