Islet transplantation in spontaneously diabetic BB/Wor rats

We investigated the effectiveness of islet transplantation as therapy in an animal model of spontaneous type I (insulin-dependent) diabetes mellitus. Grafting MHC-matched and -mismatched islets with the spontaneously diabetic BB rat as a model has been previously reported to result in recurrence of...

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Published inDiabetes (New York, N.Y.) Vol. 38; no. 9; pp. 1148 - 1154
Main Authors HEGRE, O. D, ENRIQUEZ, A. J, KETCHUM, R. J, WEINHAUS, A. J, SERIE, J. R
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Diabetes Association 01.09.1989
Subjects
Animals
Animals, Newborn
Biological and medical sciences
Case studies
Cell Separation - methods
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - surgery
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Islands of Langerhans
Islets of Langerhans
Islets of Langerhans - immunology
Islets of Langerhans Transplantation
Kidney
Major Histocompatibility Complex
Male
Medical sciences
Rats
Rats, Inbred BB
Rats, Inbred F344
Recurrence
Transplantation Immunology
Transplantation, Homologous
Endocrinopathy
Rat
Rodentia
Langerhans islet
Homograft
Transplantation
Vertebrata
Mammalia
Treatment
Animal
Surgery
Insulin dependent diabetes
Endocrine pancreas
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Summary:We investigated the effectiveness of islet transplantation as therapy in an animal model of spontaneous type I (insulin-dependent) diabetes mellitus. Grafting MHC-matched and -mismatched islets with the spontaneously diabetic BB rat as a model has been previously reported to result in recurrence of the disease in the grafted tissue. When transplanted with nonimmunogenic islets isolated by nonenzymatic culture, we found that MHC-matched grafts proved to be susceptible to disease recurrence when allowed to remain in situ until ketosis developed in the host. Conversely, the MHC-mismatched grafts did not succumb to the disease process despite the destruction of the beta-cell population of the endogenous pancreas. Four manifestly hyperglycemic BB/Wor rats received sufficient islet mass by allotransplantation to reverse this state. All four animals had ameliorated conditions, and three of the four were restored to a normoglycemic state. Recurrence of diabetes in the BB rat was not observed.
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ISSN:0012-1797
1939-327X
DOI:10.2337/diab.38.9.1148