Assessment of acute traumatic cervical spinal cord injury using conventional magnetic resonance imaging in combination with diffusion tensor imaging–tractography: a retrospective comparative study

• Published in: European spine journal Vol. 31; no. 7; pp. 1700 - 1709
• Main Authors: Zhu, Fengzhao, Wang, Yulong, Kong, Xiangchuang, Liu, Yuan, Zeng, Lian, Jing, Xirui, Yao, Sheng, Chen, Kaifang, Yang, Lian, Guo, Xiaodong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2022; Springer Nature B.V
• Subjects: Anisotropy; Diffusion coefficient; Dithiothreitol; Hemorrhage; Magnetic resonance imaging; Medicine; Medicine & Public Health; Neurosurgery; Original Article; Spinal cord injuries; Substantia alba; Surgical Orthopedics; Diffusion tensor tractography; Magnetic resonance imaging; Spinal cord injury; Diffusion tensor imaging
• ISSN: 0940-6719; 1432-0932
• DOI: 10.1007/s00586-022-07207-w

Purpose The application of conventional magnetic resonance imaging (MRI) in combination with diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) to diagnose acute traumatic cervical SCI has not been studied. This study explores the role of MRI with DTI-DTT in the diagnosis of acute traumatic cervical spinal cord injury (SCI). Methods Thirty patients with acute traumatic cervical SCI underwent conventional MRI and DTI-DTT. Conventional MRI was used to detect the intramedullary lesion length (IMLL) and intramedullary hemorrhage length (IMHL). DTI was used to detect the spinal cord’s fractional anisotropy (FA) and apparent diffusion coefficient value, and DTT detected the imaginary white matter fiber volume and the connection rates of fiber tractography (CRFT). Patients’ neurological outcome was determined using the American Spinal Injury Association (ASIA) Impairment Scale (AIS) grades. Results Patients were divided into group A (without AIS grade conversion) and group B (with AIS grade conversion). The IMLL and IMHL of group A were significantly higher than those of group B. The FA and CRFT of group A were significantly lower than those of group B. The final AIS grade was negatively correlated with the IMLL and IMHL, and positively correlated with the FA and CRFT. According to imaging features based on conventional MRI and DTI-DTT, we propose a novel classification and diagnostic procedure. Conclusions The combination of conventional MRI with DTI-DTT is a valid diagnostic approach for SCI. Lower IMLL and IMHL, and higher FA value and CRFT are linked to better neurological outcomes.