Vitamin E intake and paraoxonase 1 (PON1) rs662 genetic polymorphism are associated with colorectal cancer risk in a Korean population

• Published in: International journal of food sciences and nutrition Vol. 74; no. 4; pp. 510 - 521
• Main Authors: Bui, Quynh-Anh, Gunathilake, Madhawa, Lee, Jeonghee, Oh, Jae Hwan, Chang, Hee Jin, Sohn, Dae Kyung, Shin, Aesun, Kim, Jeongseon
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 19.05.2023; Taylor & Francis Ltd
• Subjects: Alleles; aryldialkylphosphatase; Cancer; carcinogenesis; case-control studies; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; confidence interval; Food science; Gene polymorphism; genetic polymorphism; genotype; Health risks; Nutrition; odds ratio; Paraoxonase; Paraoxonase 1; Polymorphism; PON1; Risk; Tocopherol; Vitamin E; paraoxonase 1; colorectal cancer; Vitamin E; PON1
• ISSN: 0963-7486; 1465-3478; 1465-3478
• DOI: 10.1080/09637486.2023.2220986

Vitamin E and paraoxonase 1 (PON1) are associated with cancer development. However, their interactive effect on colorectal cancer (CRC) risk is inconclusive. We conducted a case-control study including 1,351 CRC patients and 2,670 controls at the Korean National Cancer Centre (KNCC). There was an inverse association between vitamin E intake and CRC risk (odds ratio (OR) = 0.31; 95% confidence interval (CI) = 0.22-0.42). We identified a reduced CRC risk among individuals with CC genotype of PON1 rs662 polymorphism compared with subjects carrying the T allele (OR = 0.74; 95% CI = 0.61-0.90). The highest interaction between vitamin E intake and PON1 rs662 variants was significant for the subjects carrying the CC genotype (p-interaction = 0.014). This study provided further supporting evidence that vitamin E intake is associated with lower odds of CRC. Furthermore, the activity of vitamin E is strengthened among individuals carrying C allele of the PON1 rs662 polymorphism.