Evaluating the severity of aortic coarctation in infants using anatomic features measured on CTA

• Published in: European radiology Vol. 31; no. 3; pp. 1216 - 1226
• Main Authors: Yu, Yiming, Wang, Yubo, Yang, Maoqing, Huang, Meiping, Li, Jun, Jia, Qianjun, Zhuang, Jian, Huang, Liyu
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2021; Springer Nature B.V
• Subjects: Algorithms; Alternations; Aorta; Aorta - diagnostic imaging; Aortic Coarctation - diagnostic imaging; Area; Cardiac; Congenital diseases; Coronary vessels; Diagnostic Radiology; Diameters; Discriminant analysis; Echocardiography; Evaluation; Humans; Image reconstruction; Imaging; Infant; Infants; Internal Medicine; Interventional Radiology; Learning algorithms; Machine learning; Medicine; Medicine & Public Health; Model accuracy; Neuroradiology; Proportional Hazards Models; Radiology; Regression analysis; Retrospective Studies; Thorax; Ultrasound; Weight; Computed tomography angiography; Aortic coarctation; Risk assessment; Re-coarctation; Machine learning
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-020-07238-1

Objectives A machine learning model was developed to evaluate the severity of aortic coarctation (CoA) in infants based on anatomical features measured on CTA. Methods In total, 239 infant patients undergoing both thorax CTA and echocardiography were retrospectively reviewed. The patients were assigned to either mild or severe CoA group based on their pressure gradient on echocardiography. They were further divided into patent ductus arteriosus (PDA) and non-PDA groups. The anatomical features were measured on double-oblique multiplanar reconstructed CTA images. Then, the optimal features were identified by using the Boruta algorithm. Subsequently, the coarctation severity was classified using linear discriminant analysis (LDA). We further investigated the relationship between the anatomical features and re-coarctation using Cox regression. Results Four anatomical features showed significant differences between the mild and severe CoA groups, including the smallest aortic cross-sectional area indexed to body surface area ( p  < 0.001), the narrowest aortic diameter (CoA diameter) indexed to height ( p  < 0.001), the diameter of the descending aorta at the diaphragmatic level ( p  < 0.001) and weight ( p  = 0.005). With these features, accuracy of 88.6% and 90.2%, sensitivity of 65.0% and 72.1%, and specificity of 92.9% and 100% were obtained for classifying the CoA severity in the non-PDA and PDA groups, respectively. Moreover, CoA diameter indexed to weight was associated with the risk of re-coarctation. Conclusions CoA severity can be evaluated by using LDA with anatomical features. When quantifying the severity of CoA and risk of re-coarctation, both anatomical alternations at the CoA site and the growth of the patients need to be considered. Key Points • CTA is routinely ordered for infants with coarctation of the aorta; however, whether anatomical variations observed with CTA could be used to assess the severity of CoA remains unknown. • Using the diameter and area of the coarctation site adjusted to body growth as features, the LDA model achieved an accuracy of 88.6% and 90.2% in differentiating between the mild and severe CoA patients in the non-PDA group and PDA group, respectively. • The narrowest aortic diameter (CoA diameter) indexed to weight has a hazard ratio of 10.29 for re-coarctation.