Short-chain fatty acids: linking diet, the microbiome and immunity

• Published in: Nature reviews. Immunology Vol. 24; no. 8; pp. 577 - 595
• Main Authors: Mann, Elizabeth R., Lam, Ying Ka, Uhlig, Holm H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2024; Nature Publishing Group
• Subjects: 631/250; 631/250/249/2510; Acetic acid; Allergies; Animals; Antibiotics; Autoimmune diseases; Autoimmunity; Biomedical and Life Sciences; Biomedicine; Butyrates - metabolism; Cancer therapies; Cell differentiation; Diet; Effector cells; Environmental factors; Epithelial cells; Evolutionary conservation; Fatty acids; Fatty Acids, Volatile - immunology; Fatty Acids, Volatile - metabolism; Food allergies; Gastrointestinal Microbiome - immunology; Hepatocytes; Humans; Immunology; Intestine; Liver diseases; Lymphocytes B; Lymphocytes T; Metabolic engineering; Metabolites; Microbial activity; Microbiomes; Microbiota; Microbiota - immunology; Mucosal immunity; Phagocytes; Protein turnover; Reproductive system; Review Article
• ISSN: 1474-1733; 1474-1741; 1474-1741
• DOI: 10.1038/s41577-024-01014-8

The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in the gut and other organs is determined by environmental factors, such as diet and use of antibiotics, that shape the diversity and metabolism of the microbiota. SCFAs regulate epithelial barrier function as well as mucosal and systemic immunity via evolutionary conserved processes that involve G protein-coupled receptor signalling or histone deacetylase activity. Indicatively, the anti-inflammatory role of butyrate is mediated through direct effects on the differentiation of intestinal epithelial cells, phagocytes, B cells and plasma cells, and regulatory and effector T cells. Intestinally derived SCFAs also directly and indirectly affect immunity at extra-intestinal sites, such as the liver, the lungs, the reproductive tract and the brain, and have been implicated in a range of disorders, including infections, intestinal inflammation, autoimmunity, food allergies, asthma and responses to cancer therapies. An ecological understanding of microbial communities and their interrelated metabolic states, as well as the engineering of butyrogenic bacteria may support SCFA-focused interventions for the prevention and treatment of immune-mediated diseases. Short-chain fatty acids (SCFAs) are microbial metabolites that regulate mucosal barrier integrity and immune cell functions. This Review summarizes latest insights into how SCFA levels might determine inflammatory and allergic disease outcomes by controlling the crosstalk between diet, the microbiome and immunity.