Hederacolchiside C inhibits Enterovirus 71 propagation through activating innate immunity

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 25; no. 12; pp. 1074 - 1077
• Main Authors: Wang, Yan-Er, Kang, Nai-Xin, Zhao, Jian-Ping, Liu, Yan-Li, Li, Kun-Ping, Xu, Qiong-Ming, Khan, Ikhlas A., Yang, Shilin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2019
• Subjects: Animals; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Enterovirus 71; Enterovirus A, Human - drug effects; Enterovirus A, Human - immunology; Hand, Foot and Mouth Disease - drug therapy; Hand, Foot and Mouth Disease - immunology; Hand, Foot and Mouth Disease - virology; Hederacolchiside C; Host-Pathogen Interactions - drug effects; Host-Pathogen Interactions - immunology; Humans; Immunity, Innate - drug effects; Innate immunity; MAVS signaling; Mice; Natural products; Oleanolic Acid - analogs & derivatives; Oleanolic Acid - pharmacology; Oleanolic Acid - therapeutic use; Pulsatilla - chemistry; Saponins - pharmacology; Saponins - therapeutic use; Virus Replication - drug effects; Virus Replication - immunology; Enterovirus 71; Innate immunity; Natural products; MAVS signaling; Hederacolchiside C
• ISSN: 1341-321X; 1437-7780
• DOI: 10.1016/j.jiac.2019.07.010

Enterovirus 71 (EV71), a newly emerging life-threatening pathogen induces hand-foot-mouth disease (HFMD), no effective vaccines or specific anti-viral treatments are currently available. In this study, the activity of hederacolchiside C (HSC) against EV71 was investigated, and the antiviral mechanism was explored. HSC displayed apparent antiviral activity in EV71-infected cells probably through activating the host innate immunity. Comparing with EV71-infected group at 24 hpi, the group pretreated with HSC dramatically increased the expression of MAVS, p-IRF3, IRF3 and IFN-β, the innate immune effectors related to innate immunity. In addition, HSC displayed stronger antiviral activity in EV71-infected suckling mice in comparison with Ribavirin, a broad-spectrum antiviral drug. The results suggest that HSC could have potential as a pharmaceutical drug for HFMD.