Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease

• Published in: Immunologic research Vol. 70; no. 2; pp. 161 - 173
• Main Authors: Tsiogkas, Sotirios G., Mavropoulos, Αthanasios, Skyvalidas, Dimitrios N., Patrikiou, Eleni, Ntavari, Niki, Daponte, Athina Ioanna, Grammatikopoulou, Maria G., Dardiotis, Efthimios, Roussaki-Schulze, Aggeliki-Victoria, Sakkas, Lazaros I., Zafiriou, Efterpi, Bogdanos, Dimitrios P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2022; Springer Nature B.V
• Subjects: Allergology; Anthocyanins - therapeutic use; Arthritis; Arthritis, Psoriatic - drug therapy; Biomedical and Life Sciences; Biomedicine; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes; Cell culture; Cytokines; Functional foods & nutraceuticals; Humans; Immunology; Immunomodulation; Inflammation; Interferon-gamma; Interleukin 10; Interleukin 17; Internal Medicine; Ionomycin; Leukocytes, Mononuclear; Lymphocytes; Lymphocytes T; Medicine/Public Health; Original Article; Peripheral blood mononuclear cells; Psoriasis; Psoriatic arthritis; γ-Interferon; IFNγ; Diet supplement; IL-17A; Psoriasis; Immunoregulation; Inflammation; Immunonutrition; PBMCs
• ISSN: 0257-277X; 1559-0755; 1559-0755
• DOI: 10.1007/s12026-021-09251-y

The anthocyanidin delphinidin reduces psoriasiform lesions and inflammatory mediators in human cell culture systems. Its role in psoriatic disease has not yet been investigated. We assessed delphinidin’s in vitro immunomodulatory effect on ex vivo stimulated peripheral blood mononuclear cells (PBMCs...