The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects

• Published in: Journal of endocrinological investigation Vol. 43; no. 7; pp. 995 - 1000
• Main Authors: Morales-Gurrola, G., Simental-Mendía, L. E., Castellanos-Juárez, F. X., Salas-Pacheco, J. M., Guerrero-Romero, F.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2020; Springer Nature B.V
• Subjects: Adult; Aged; Blood Glucose - metabolism; Blood pressure; Body Mass Index; Body weight; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cholesterol; Cholesterol, HDL - blood; Cross-Sectional Studies; Diabetes mellitus; Endocrinology; Female; Genotype & phenotype; Health risk assessment; Heart Disease Risk Factors; High density lipoprotein; Humans; Hyperglycemia; Hyperglycemia - complications; Hyperglycemia - epidemiology; Hyperglycemia - metabolism; Hypertension - complications; Hypertension - epidemiology; Hypertension - metabolism; Hypertriglyceridemia; Hypertriglyceridemia - complications; Hypertriglyceridemia - epidemiology; Hypertriglyceridemia - metabolism; Ideal Body Weight - physiology; Internal Medicine; Liver diseases; Male; Malignancy; Medical treatment; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Obesity; Obesity - metabolism; Original Article; Overweight; Phenotype; Phenotypes; Population studies; Pregnancy; Risk Factors; Triglycerides; Triglycerides - blood; Young Adult; Triglycerides; Blood pressure; Glucose; Metabolically obese normal-weight; TyG index; HDL cholesterol
• ISSN: 1720-8386; 0391-4097; 1720-8386
• DOI: 10.1007/s40618-020-01184-x

Purpose The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors. Methods Apparently healthy men and non-pregnant women aged 20–65 years were enrolled in a population-based cross-sectional study. Overweight, obesity, smoking, alcohol consumption, pregnancy, diagnosis of hypertension, diabetes, cardiovascular disease, liver disease, renal disease, malignancy, and medical treatment were exclusion criteria. Subjects were allocated into the MONW or normal-weight groups. MONW phenotype was defined by normal weight and the presence of at least one of the following cardiovascular risk factors: elevated blood pressure, hyperglycemia, hypertriglyceridemia, and low HDL cholesterol. Results A total of 542 subjects were enrolled and allocated into the MONW ( n  = 354) and normal-weight ( n  = 188) groups. The adjusted logistic regression analysis showed that the elevated TyG index is significantly associated with the presence of MONW phenotype (OR = 11.14; 95% CI 6.04–20.57), hyperglycemia (OR = 3.18; 95% CI 1.95–5.21), hypertriglyceridemia (OR = 399.19; 95% CI 94.01–1694.98), and low HDL-C (OR = 2.60; 95% CI 1.74–3.87), but not with elevated blood pressure (OR = 1.55; 95% CI 0.93–2.60). Conclusion Results of this study support that the TyG index may be a useful indicator to detect MONW phenotype and associated cardiovascular risk factors.