Levels of trace blood elements associated with severe sleep disturbance in maintenance hemodialysis patients

• Published in: Sleep & breathing Vol. 25; no. 4; pp. 2007 - 2013
• Main Authors: Xu, Shilin, Zou, De’e, Tang, Ruiying, Li, Shuting, Chen, Wenxuan, Wen, Luona, Liu, Yun, Liu, Yan, Zhong, Xiaoshi
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2021; Springer Nature B.V
• Subjects: Aged; Blood levels; Copper; Cross-Sectional Studies; Dentistry; Female; Hemodialysis; Humans; Internal Medicine; Lead; Male; Manganese; Medicine; Medicine & Public Health; Middle Aged; Neurology; Otorhinolaryngology; Parathyroid; Parathyroid hormone; Patient Acuity; Patients; Pediatrics; Pneumology/Respiratory System; Renal Dialysis; Selenium; Selenium - blood; Sleep; Sleep Breathing Physiology and Disorders • Original Article; Sleep Wake Disorders - blood; Supplements; Trace elements; Trace Elements - blood; Sleep disturbance; Blood selenium; Trace elements; Maintenance hemodialysis
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-021-02336-w

Purpose Sleep disturbance is frequently observed in patients on maintenance hemodialysis (MHD), and this population usually presents imbalances in trace elements. We investigated the association between blood trace element levels and sleep quality in patients on MHD. Methods This cross-sectional and single-center study was performed in September 2019. Patients regularly undergoing hemodialysis for > 3 months at our center were recruited, and demographic, clinical, and laboratory parameters were recorded. The Pittsburgh Sleep Quality Index (PSQI) was applied to define sleep disturbance. Blood trace element (zinc, manganese, copper, selenium, and lead) levels were measured using an inductively coupled plasma mass spectrometer. Results In total, 121 patients on MHD (male/female = 68:53) were enrolled in the study (mean age 63.7 ± 13.9 years, median dialysis vintage 38.0 [20.0, 60.0] months). According to PSQI, 56 (46%) patients experienced severe sleep disturbance. These patients were characterized by older age, higher serum parathyroid hormone levels, and lower blood selenium levels (all P < 0.05). No significant differences in blood zinc, manganese, copper, and lead levels were observed between groups. Univariate binary logistic regression showed that lower blood selenium levels were associated with severe sleep disturbance (odds ratio = 0.976, 95% confidence interval: 0.954–0.999, P = 0.038). Multivariate analyses also confirmed the results after adjusting for confounding factors. Conclusion Our study indicated an association between lower blood selenium levels and the occurrence of severe sleep disturbances in patients on MHD. However, a prospective study with a larger sample size and assessing the importance of selenium supplementation are needed to confirm the results.