Microwave synthesis of 3D rambutan-like CuO and CuO/reduced graphene oxide modified electrodes for non-enzymatic glucose detection

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 4; no. 7; pp. 1247 - 1253
• Main Authors: Zheng, Jianzhong, Zhang, Wuxiang, Lin, Zhongqiu, Wei, Chan, Yang, Weize, Dong, Peihui, Yan, Yaru, Hu, Shirong
• Format: Journal Article
• Language: English
• Published: England 21.02.2016
• Subjects: Biosensors; COMPOSITES; COPPER OXIDE; CUPRIC OXIDE; Electrodes; Glucose; Graphene; graphene oxide; microstructure; microwave treatment; MICROWAVES; OXIDES; scanning electron microscopy; silver; silver chloride; surface area; Three dimensional; Transmission electron microscopy; X-ray diffraction
• ISSN: 2050-750X; 2050-7518; 2050-7518
• DOI: 10.1039/c5tb02624e

A novel type of cupric oxide (CuO) particles-reduced graphene oxide (r-GO) modified electrode has been fabricated through a facile, simple and fast microwave method. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), and X-ray diffraction (XRD) were employed to characterize the morphologies and structures of the as-prepared samples. The results reveal that the CuO/r-GO composite was a porous 3D rambutan-like microstructure with high surface area. Then the CuO and CuO/r-GO electrodes were constructed for their use as non-enzymatic glucose biosensors owing to their high-performance and sensitivity under alkaline conditions. The proposed biosensor exhibits glucose concentrations in the range from 0.50 μM to 3.75 mM. Besides, chronoamperometry demonstrates a desirable sensitivity of 52.1 μA mM −1 at an applied potential of 0.50 V ( vs. Ag/AgCl), with a detection limit of 0.10 μM (signal/noise = 3). Most importantly, this non-enzymatic glucose biosensor has highly stable characteristics and can be manufactured into a long-term stability electrode for its application in various complicated circumstances. All these results confirm that this CuO/r-GO biosensor is a promising active material with excellent analytical properties for non-enzymatic glucose detection. Illustration of the glucose biosensing mechanism based on CuO/r-GO composites.