Alpha-1-antitrypsin phenotypes and HLA-B27 typing in uveitis patients in southeast Iran

• Published in: Clinical biochemistry Vol. 38; no. 5; pp. 425 - 432
• Main Authors: Ghavami, Saeid, Hashemi, Mohammad, Shahriari, Hossain Ali, Bajestani, Saeed Naghibzadeh, de Serres, Frederick J., Moghaddam, Ebrahim Miri, Kazemi, Morteza, Alavian, Seyed Moayed, Taheri, Mohsen, Blanco, Ignacio, Fernandez Bustillo, Enrique
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2005
• Subjects: alpha 1-Antitrypsin - genetics; Alpha-1-antitrypsin deficiency; Case-Control Studies; Ethnic Groups - genetics; HLA-B27; HLA-B27 Antigen - genetics; Humans; Inflammatory eye diseases; Iran; Isoelectric focusing; Panuveitis - genetics; Phenotype; Trypsin Inhibitors - blood; Uveitis; Uveitis - genetics; Uveitis, Anterior - genetics; Uveitis, Posterior - genetics; Iran; Isoelectric focusing; Inflammatory eye diseases; HLA-B27; Uveitis; Alpha-1-antitrypsin deficiency
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2005.02.006

Uveitis is an eye disease that affects humans worldwide. Inflammation of the uveal tract is termed uveitis. Alpha-1-antitrypsin (AAT) deficiency is one of many factors that may be involved in abnormalities such as liver and lung disease, inflammatory joint diseases, and inflammatory eye diseases. In this study, the role of AAT in uveitis is analyzed. AAT phenotyping and serum-trypsin inhibitory capacity (S-TIC) experiments were performed on 103 patients who were referred to the ALZAHRA eye center in Zahedan (southeast of Iran). The same experiments were performed on 167 people who did not suffer from any eye or systemic diseases and served as a control group. The results revealed that the frequency of M 1S, M 2S, M 1Z, and MV phenotypes were significantly higher in uveitis patients ( P < 0.001). There was no difference in AAT phenotype frequencies between various types of uveitis ( P = 0.1). AAT deficiency appears to be a risk factor for uveitis in southeast Iran. More investigation is needed to establish potential benefits of AAT phenotyping tests and AAT therapy in the diagnosis and treatment of uveitis cases with unclear etiology.