A Novel NADH Model: Design, Synthesis, and its Chiral Reduction and Fluorescent Emission

A novel chiral nicotinamide adenine dinucleotide hydrogen (NADH) model with C 3 symmetry was designed and synthesized. Hydrogens at the C‐4 position of all dihydropyridine rings in the inner part of the bowl could transfer to the substrate with powerful enantioselectivity. This novel C 3 symmetrical...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 351; no. 18; pp. 3045 - 3050
Main Authors Wang, Nai-Xing, Zhao, Jia
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.12.2009
Wiley
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
chiral NADH model
enantioselectivity
fluorescence
magnesium(II)
Physical Sciences
Science & Technology
synthesis
enantioselectivity
synthesis
magnesium(II)
ASYMMETRIC TRANSFER HYDROGENATION
chiral NADH model
BENZOYLFORMATE
MIMICS
STEREOSELECTIVE REDUCTION
AUXILIARY
HYDRIDE TRANSFER
LIGANDS
fluorescence
1,4-DIHYDROPYRIDINES
ESTERS
CHEMISTRY
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Summary:A novel chiral nicotinamide adenine dinucleotide hydrogen (NADH) model with C 3 symmetry was designed and synthesized. Hydrogens at the C‐4 position of all dihydropyridine rings in the inner part of the bowl could transfer to the substrate with powerful enantioselectivity. This novel C 3 symmetrical NADH model is capable of fluorescence emission at 455 nm when excited at 390 nm.
Bibliography:Natural Science Foundation of China - No. 20472090; No. 10576034
ark:/67375/WNG-6CJ37W69-H
ArticleID:ADSC200900610
istex:C30B4090A2EAA7A916B69E73032298D40EF45178
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200900610