Clinical Features and Genetic Polymorphism in Chinese Patients with Erythrodermic Psoriasis in a Single Dermatologic Clinic

• Published in: Molecular diagnosis & therapy Vol. 24; no. 1; pp. 85 - 93
• Main Authors: Lo, Yang, Chiu, Hsien-Yi, Tsai, Tsen-Fang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2020; Springer Nature B.V
• Subjects: Adult; Age; Alleles; Antigens; Arthritis; Biomarkers; Biomedical and Life Sciences; Biomedicine; Biopsy; Cancer Research; Comorbidity; Complications; Drb1 protein; Family medical history; Female; Gene Frequency; Gene polymorphism; Genetic Association Studies - methods; Genetic Predisposition to Disease; Genetics; Genotype; Genotyping; Histocompatibility antigen HLA; HLA Antigens - genetics; HLA Antigens - immunology; Hospitals; Human Genetics; Humans; Laboratory Medicine; Leukocytes; Male; Middle Aged; Molecular Medicine; Patients; Pharmacotherapy; Phenotype; Plaques; Polymorphism; Polymorphism, Genetic; Population genetics; Psoriasis; Psoriasis - diagnosis; Psoriasis - etiology; Psoriasis - therapy; Psoriasis vulgaris; Psoriatic arthritis; Retrospective Studies; Short Communication; Standard deviation; Studies
• ISSN: 1177-1062; 1179-2000
• DOI: 10.1007/s40291-019-00441-x

Background Erythrodermic psoriasis (EP) is a rare variant of psoriasis that involves more complications and poorer biologic drug survival than plaque-type psoriasis vulgaris (PV). No prior study has explored human leukocyte antigen (HLA) or other genetic polymorphisms in patients with EP. Objectives Our objective was to describe the clinical features, comorbidities, and HLA polymorphisms among Chinese patients with EP. Methods We enrolled consecutive patients with EP from our clinic, with EP defined as generalized confluent erythematous thin plaques covering at least 80% body surface area. Patients were categorized as having primary or secondary EP. Aggravating factors, comorbidities including psoriatic arthritis, family history of psoriasis, age of onset, and treatment history were also identified. Genetic studies were performed for HLA - C and HLA - DRB1 , and the results were compared with those from a healthy population and patients with PV. Results Of the 63 included patients, the male to female ratio was 2.71:1. Five (7.9%) patients had primary EP, and 58 (92.1%) had secondary EP. Genotyping of HLA - C and HLA - DRB1 was available in 61 and 58 subjects, respectively. HLA - C*0102 was the most frequent HLA - C allele (34.4%), followed by HLA - C*0702 (18.0%). The frequency of HLA - C*0602 allele (4.1%) was lower than in patients with plaque-type psoriasis (4.1 vs. 16.3%, corrected p value [ P c ] = 0.02) and similar to that in the healthy population in Taiwan. The most frequent HLA - DRB1 allele was HLA - DRB1*0901 (20.7%), followed by HLA - DRB1*0803 (13.8%). An increased prevalence of psoriatic arthritis (61.9%) and higher male predominance were also noted in comparison with PV. Conclusions There are HLA differences in Chinese patients with EP compared with patients with PV. The incidence of psoriatic arthritis is also higher. The implications of the above findings await further investigation.