Effects of weight change on all causes, digestive system and other causes mortality in Southern Italy: a competing risk approach

• Published in: International Journal of Obesity Vol. 46; no. 1; pp. 113 - 120
• Main Authors: Campanella, Angelo, Sorino, Paolo, Bonfiglio, Caterina, Mirizzi, Antonella, Franco, Isabella, Bianco, Antonella, Misciagna, Giovanni, Caruso, Maria Gabriella, Cisternino, Anna Maria, Notarnicola, Maria, Tutino, Valeria, D’Attoma, Benedetta, Osella, Alberto Ruben
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2022; Nature Publishing Group
• Subjects: 692/308/174; 692/700/2817; Adult; Body Mass Index; Body size; Body-Weight Trajectory; Cardiovascular diseases; Correlation analysis; Digestive system; Digestive System - physiopathology; Epidemiology; Fatalities; Female; Gastrointestinal diseases; Health Promotion and Disease Prevention; Humans; Internal Medicine; Italy - epidemiology; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Mortality; Mortality - trends; Prospective Studies; Public Health; Risk; Root-mean-square errors; Variation; Weight; Italy
• ISSN: 0307-0565; 1476-5497; 1476-5497
• DOI: 10.1038/s41366-021-00954-8

Weight change is associated with all causes of death, cardiovascular, and cancer mortality and a heterogeneous group of other causes of death. We aimed to estimate the effect of weight change on all causes and cause-specific mortality in a cohort with a high prevalence of deaths due to diseases of the digestive system.MethodsIn this prospective cohort study, 2230 subjects aged 30 to 50 years were examined. The study consisted of a 32-year longitudinal study period (January 1985 to December 2017) and mortality follow-up. Outcomes were mortality from all causes and deaths from gastrointestinal disease. Root Mean Squared Error (RMSE) was evaluated to capture individual residual variation in Body Mass Index (BMI) after adjustment for baseline BMI, and the relationship of residual variation with mortality was calculated as cumulative incidence function and cause-specific hazard (CSH) rate.ResultsIn total, 793 participants died during the follow-up, 96 of them due to Digestive system causes. Magnitude of residual variation weight in the last quintile was associated with all-cause mortality (relative risk, 2.00; 95% CI, 1.54–2.59) and Digestive system causes (relative risk, 3.82; 95% CI, 1.86–7.81).ConclusionThe findings suggest an association between weight change and gastrointestinal disease mortality. Epidemiological works studying the correlation between weight change and mortality should consider this aspect.