The role of macrophage subtypes and exosomes in immunomodulation

Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage...

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Published inCellular & molecular biology letters Vol. 27; no. 1; pp. 83 - 18
Main Authors Gharavi, Abdulwahab Teflischi, Hanjani, Niloofar Asadi, Movahed, Elaheh, Doroudian, Mohammad
Format Journal Article
LanguageEnglish
Published London BioMed Central 03.10.2022
BMC
Subjects
Exosomes
Inflammation
Macrophage polarization
Macrophages
Review Letter
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Summary:Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage polarization plays a key role in the initiation and development of a wide range of diseases. This study aims to give an overview of macrophage polarization, their different subtypes, and the importance of alternatively activated M2 macrophage and classically activated M1 macrophage in immune responses and pathological conditions. This review provides insight on the role of exosomes in M1/M2-like macrophage polarization and their potential as a promising therapeutic candidate.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
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ObjectType-Review-2
ISSN:1425-8153
1689-1392
1689-1392
DOI:10.1186/s11658-022-00384-y