Cystatin C reference values and aging

The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were c...

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Published inClinical biochemistry Vol. 39; no. 6; pp. 658 - 661
Main Authors Ognibene, Agostino, Mannucci, Edoardo, Caldini, Anna, Terreni, Alessandro, Brogi, Marco, Bardini, Gianluca, Sposato, Iolanda, Mosconi, Valentina, Salvadori, Benedetta, Rotella, Carlo Maria, Messeri, Gianni
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2006
Subjects
Adult
Creatinine
Cystatin C
Cystatins - blood
Female
Glomerular filtration rate
Humans
Male
Middle Aged
Reference value
Reference Values
Creatinine
Reference value
Cystatin C
Glomerular filtration rate
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ISSN0009-9120
1873-2933
DOI10.1016/j.clinbiochem.2006.03.017

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Summary:The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging. The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected. CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (< 45 years, < 0.95 mg/L and > 45 years, < 1.20 mg/L). The use of CysC reference values adjusted for age should be carefully taken into consideration.
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ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2006.03.017