Independent association of severity of obstructive sleep apnea with lipid metabolism of atherogenic index of plasma (AIP) and apoB/apoAI ratio

• Published in: Sleep & breathing Vol. 24; no. 4; pp. 1507 - 1513
• Main Authors: Cao, Bing, Fan, Zeqin, Zhang, Yanhong, Li, Taoping
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2020; Springer Nature B.V
• Subjects: Apnea; Blood glucose; Cardiovascular diseases; Cholesterol; Correlation analysis; Dentistry; Dyslipidemia; Fasting; High density lipoprotein; Insulin; Internal Medicine; Laboratory testing; Lipid metabolism; Low density lipoprotein; Medicine; Medicine & Public Health; Neurology; Otorhinolaryngology; Pediatrics; Pneumology/Respiratory System; Sleep; Sleep apnea; Sleep Breathing Physiology and Disorders • Original Article; Sleep disorders; Lipid profile; Atherogenic index of plasma (AIP); Cardiovascular diseases; apoB/apoAI ratio; Obstructive sleep apnea
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-020-02016-1

Background Cardiovascular diseases (CVDs) are highly prevalent in obstructive sleep apnea (OSA), and dyslipidemia is an important factor. Atherogenic index of plasma (AIP, log[TG/HDL-C]) and apolipoproteinB to apolipoproteinAI ratio (apoB/apoAI ratio) are considered high quality predictors of cardiovascular risk. However, the associations between OSA severity and AIP and apoB/apoAI ratio remained unclear. Methods A retrospective study was performed in 284 patients. Subjects were assessed with polysomnography (PSG) test, and OSA severity was defined by AHI. Data collected included anthropometric measurements, medical history, sleep parameters, fasting plasma lipids, fasting blood glucose, and insulin. Results Participants were classified based on AHI into the following groups: control group ( n  = 28), mild group ( n  = 52), moderate group ( n  = 53), and severe group ( n  = 151). Triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), apoAI, AIP, apoB/apoAI ratio (low-density lipoprotein cholesterol), LDL-C/HDL-C ratio, and HDL-C/apoAI ratio showed statistical significance among AHI subgroups ( P  < 0.05). The Pearson correlation analysis revealed that AIP ( r  = 0.32, P  < 0.001) and apoB/apoAI ratio ( r  = 0.24, P  < 0.001) were positively related to AHI. By multivariate linear regression analysis, we found that AHI was independently related to AIP (β = 0.24, P  = 0.001), apoB/apoAI ratio (β = 0.24, P <0.001). Conclusion AHI was independently correlated with AIP and apoB/apoAI ratio in OSA. Our findings suggested that AIP and apoB/apoAI ratio increased with OSA severity, which might be partly responsible for the high risk of CVDs in OSA.