Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines

Idiosyncratic drug-induced liver injury mimics acute and chronic liver disease. It is under recognized and underrecognised because of the lack of pathognomonic diagnostic serological markers. Its consequences may vary from being asymptomatic to self-limiting illness to severe liver injury leading to...

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Published inHepatology international Vol. 15; no. 2; pp. 258 - 282
Main Authors Devarbhavi, Harshad, Aithal, Guruprasad, Treeprasertsuk, Sombat, Takikawa, Hajime, Mao, Yimin, Shasthry, Saggere M., Hamid, Saeed, Tan, Soek Siam, Philips, Cyriac Abby, George, Jacob, Jafri, Wasim, Sarin, Shiv K.
Format Journal Article
LanguageEnglish
Published New Delhi Springer India 01.04.2021
Springer Nature B.V
Subjects
Colorectal Surgery
Guidelines
Hepatology
Hepatotoxicity
Injury prevention
Liver
Liver diseases
Medical treatment
Medicine
Medicine & Public Health
Surgery
Tuberculosis
Asia
DILI
Consensus
Risk factors
Guidelines
Traditional and complimentary medicine
APASL
Tuberculosis
Treatment
Medications
Drug-induced liver injury
Antituberculosis drugs
Hepatotoxicity
Monitoring
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Summary:Idiosyncratic drug-induced liver injury mimics acute and chronic liver disease. It is under recognized and underrecognised because of the lack of pathognomonic diagnostic serological markers. Its consequences may vary from being asymptomatic to self-limiting illness to severe liver injury leading to acute liver failure. Its incidence is likely to be more common in Asia than other parts of the world, mainly because of hepatotoxicity resulting from the treatment of tuberculosis disease and the ubiquitous use of traditional and complimentary medicines in Asian countries. This APASL consensus guidelines on DILI is a concise account of the various aspects including current evidence-based information on DILI with special emphasis on DILI due to antituberculosis agents and traditional and complementary medicine use in Asia.
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-021-10144-3