Hemodynamic nature of black-blood enhancement in long-term coiled cerebral aneurysms

• Published in: Neuroradiology Vol. 65; no. 12; pp. 1685 - 1694
• Main Authors: Godi, Claudia, Destro, Francesco, Garofalo, Paolo, Tombetti, Enrico, Ambrosi, Alessandro, Iadanza, Antonella, Michelozzi, Caterina, Falini, Andrea, Anzalone, Nicoletta
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023; Springer Nature B.V
• Subjects: Aneurysm; Aneurysms; Blood vessels; Cerebral blood flow; Coiling; Coils; Diagnostic Neuroradiology; Endovascular coiling; Hemodynamics; Imaging; Ischemia; Magnetic resonance imaging; Medicine; Medicine & Public Health; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Occlusion; Packing; Packing density; Radiology; Variance analysis; Magnetic Resonance Imaging; VWI; Black-blood; Aneurysm; Coil
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s00234-023-03192-z

Purpose Vessel wall imaging (VWI) with black-blood (BB) technique can demonstrate aneurysmal enhancement preluding to growth/rupture in treatment-naive cerebral aneurysms. Interestingly, recent works showed that BB enhancement may also occur in endovascularly treated aneurysms, though its meaning is controversial. Hypothesizing a flow-related mechanism of BB enhancement, we explored its relationship with incomplete occlusion status and coil packing density at DSA. Methods We analyzed the subjects undergoing 3T MRI between January 2017 and October 2020 for a previous aneurysmal coiling. All the MRI studies included pre- and post-contrast 3D BB sequences. The presence of intra-aneurysmal pre-contrast BB signal was assessed. BB enhancement (when present) was classified as follows: (1) enhancement at the neck, (2) intrasaccular/intra-coil enhancement, and (3) peripheral enhancement. Coil packing density and aneurysmal occlusion status (according to the modified Raymond-Roy classification, MRRC) were determined on post-treatment DSA and compared with BB findings using generalized linear mixed-effect model and ANOVA. Significant p values were <0.05. Results Forty-eight aneurysms from 44 patients were eligible for analysis. Pre-contrast BB signal was observed in 50% of the aneurysms and showed a relationship with baseline aneurysmal size. BB enhancement was detectable in 31 aneurysms (65%), being significantly associated with incomplete aneurysmal occlusion and reduced coil packing density at DSA. Conclusion BB enhancement of coiled aneurysms is related with increasing degrees of post-coiling aneurysmal remnants and with loose coil packing density at DSA. This supports a hemodynamic interpretation of BB enhancement in long-term coiled aneurysms.