Hypertrophic Scars and Keloids: Advances in Treatment and Review of Established Therapies

• Published in: American journal of clinical dermatology Vol. 24; no. 2; pp. 225 - 245
• Main Authors: Frech, Fabio Stefano, Hernandez, Loren, Urbonas, Rebecca, Zaken, Ghufran Abo, Dreyfuss, Isabella, Nouri, Keyvan
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2023; Springer Nature B.V
• Subjects: Angiogenesis; Collagen; Dermatology; Extracellular matrix; Fibroblasts; Medicine; Medicine & Public Health; Patients; Pharmacology/Toxicology; Pharmacotherapy; Review Article; Risk factors; Scars; Surgery; Trauma; Wound healing
• ISSN: 1175-0561; 1179-1888
• DOI: 10.1007/s40257-022-00744-6

Hypertrophic scars and keloids can have significant detrimental effects on patients both psychosocially and functionally. A careful identification of patient risk factors and a comprehensive management plan are necessary to optimize outcomes. Patients with a history of dystrophic scarring should avoid unnecessary procedures and enhance the wound-healing process using various preventive strategies. As there is no single, fully efficacious treatment modality, prevention remains the best approach in reducing aberrant scar formation. When prevention therapies fail, keloids have been shown to be respond to a variety of therapies including topical and injectable corticosteroids, 5-fluorouracil, radiotherapy, lasers, and surgical excision, all with varying efficacies. As such, management should be tailored to the individual patient’s risk factors with the use of combination therapies to reduce recurrence rates. Still, keloid and hypertrophic scar therapies are widely diverse with novel treatment modalities providing alternatives for recurring lesions. Laser-assisted drug delivery, skin priming, and novel topical therapies may provide alternative options for the management of hypertrophic scars and keloids.