Endoscopic submucosal dissection for colorectal lesions: outcomes from a United States experience

• Published in: Surgical endoscopy Vol. 36; no. 1; pp. 236 - 243
• Main Authors: Gupta, Nina, Rodríguez-Ruiz, Gabriela, Siddiqui, Uzma D., Chapman, Christopher G., Donboli, Kianoush, Hart, John, Xiao, Shu-Yuan, Waxman, Irving
• Format: Journal Article
• Language: English
• Published: New York Springer US 2022; Springer Nature B.V
• Subjects: Abdominal Surgery; Adenocarcinoma - etiology; Adenocarcinoma - surgery; Anesthesia; Cancer; Colorectal cancer; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Dissection; Endoscopic Mucosal Resection - adverse effects; Endoscopy; Gastroenterology; Gynecology; Hepatology; Humans; Learning Curve; Medicine; Medicine & Public Health; Pathology; Patients; Polyps; Proctology; Retrospective Studies; Surgery; Treatment Outcome; Tumors; United States; United States; United States > US; Endoscopic submucosal dissection; Therapeutic endoscopy; Colorectal polyp; Colorectal cancer
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-020-08262-4

Background and study aims Endoscopic submucosal dissection (ESD) is commonly used in Asia for resection of large non-pedunculated colorectal polyps (LNPCPs) and early (T1) colorectal cancers. It allows for en bloc removal and is often curative. We describe outcomes of colorectal ESD from a United States (US) academic medical center and compare this to international experiences. Methods Retrospective review was performed of colonic lesions referred to the University of Chicago Medical Center for ESD from 2012 to 2020. Clinical and procedural data were collected. Results The study included 78 lesions with mean size of 29.7 mm (range 10–100 mm). The overall en bloc resection rate was 73.1% ( n  = 57). Between the first and second half of the study, it improved from 61.5 to 84.6% ( p  = 0.02). Histology showed adenocarcinoma in fifteen lesions (19.2%). Of all neoplastic lesions ( n  = 68), resection with negative margins (R0) was achieved in 54 cases (79.4%). Adverse events occurred in 9 cases (11.5%), but most ( n  = 6, 66.7%) were successfully treated endoscopically. Follow-up endoscopy was performed in 46 patients (59.0%) at a mean interval of 6.8 months (SD ± 5.0 months) with two case of recurrent lesion (4.3%). Conclusions This study shows successful colorectal ESD outcomes at a US tertiary center. The en bloc resection rate was lower than other cohorts, but a learning curve was demonstrated. The R0 resection, lesion recurrence, and adverse event rates were similar to other non-Asian experiences, but not as favorable as in Asia [Fuccio et al. in Gastrointest Endosc 86:74–86.e17, 2017]. Increased ESD training in the US can help optimize utilization and outcomes.