Early Contrast-Enhanced MR for Diagnosing Complete Tumor Response of Locally Advanced Esophageal Squamous Cell Carcinoma After Neoadjuvant Therapy: A Retrospective Comparative Study

• Published in: Annals of surgical oncology Vol. 31; no. 7; pp. 4271 - 4280
• Main Authors: Shi, Yan-Jie, Yan, Shuo, Yang, Xin, Guan, Zhen, Li, Xiao-Ting, Wang, Lin-Lin, Dai, Liang, Sun, Ying-Shi
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2024; Springer Nature B.V
• Subjects: Aged; Cancer therapies; Contrast Media; Decision making; Esophageal cancer; Esophageal carcinoma; Esophageal Neoplasms - diagnostic imaging; Esophageal Neoplasms - pathology; Esophageal Neoplasms - therapy; Esophageal Squamous Cell Carcinoma - pathology; Esophageal Squamous Cell Carcinoma - therapy; Esophagectomy; Esophagus; Female; Follow-Up Studies; Humans; Leukocytes (neutrophilic); Lymphocytes; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Neoadjuvant Therapy; Oncology; Patients; Prognosis; Retrospective Studies; ROC Curve; Squamous cell carcinoma; Surgery; Surgical Oncology; Thoracic Oncology; Tumor-infiltrating lymphocytes; Tumors; Magnetic resonance imaging; Neoadjuvant therapy; Esophageal squamous cell carcinoma
• ISSN: 1068-9265; 1534-4681; 1534-4681
• DOI: 10.1245/s10434-024-15123-0

Background This study assessed the performance of early contrast-enhanced magnetic resonance (ECE-MR) in the detecting of complete tumor response (ypT0) in patients with esophageal squamous cell carcinoma following neoadjuvant therapy. Patients and Methods Preoperative MR images of consecutive patients who underwent neoadjuvant therapy and surgical resection were reviewed retrospectively. The accuracy of ECE-MR and T2WI+DWI was evaluated by comparing the findings with pathological results. Receiver operating characteristic curve analysis was used to assess the diagnostic performance, and DeLong method was applied to compare the areas under the curves (AUC). Chi-squared analysis was conducted to explore the difference in pathological changes. Results A total of 198 patients (mean age 62.6 ± 7.8 years, 166 men) with 201 lesions were included. The AUC of ECE-MR was 0.85 (95% CI 0.79–0.90) for diagnosing ypT1–4, which was significantly higher than that of T2WI+DWI (AUC 0.69, 95% CI 0.63–0.76, p  < 0.001). The diagnostic performance of both T2WI+DWI and ECE-MR improved with increasing tumor stage. The AUCs of ECE-MRI were higher in ypT1 and ypT2 tumors than T2WI+DWI. Degree 2–3 tumor-infiltrating lymphocytes and neutrophils were commonly seen in ypT0 tumors misdiagnosed by ECE-MR. Conclusions Visual evaluation of ECE-MR is a promising diagnostic protocol for the detection of complete tumor response, especially for differentiation with early stage tumors. The accurate diagnosis of complete tumor response after neoadjuvant therapy using imaging modalities is of important significance for clinical decision-making for patients with esophageal squamous cell carcinoma. It is hoped that early contrast-enhanced MR will provide supportive advice for the development of individualized treatment options for patients.