Effect of Long-Term Light Deprivation on α-Tocopherol Content in Rats during Ontogeny

We studied the effect of long-term light deprivation which began at different stages of ontogeny on the content of α-tocopherol in rats during the first 3 months of postnatal development. In the offspring postnatally exposed to constant darkness, the level of α-tocopherol in the liver, kidneys, hear...

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Published inBulletin of experimental biology and medicine Vol. 170; no. 3; pp. 294 - 298
Main Authors Baishnikova, I. V., Ilyina, T. N., Khizhkin, E. A., Ilyukha, V. A., Vinogradova, I. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 2021
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cardiac muscle
Cell Biology
Circadian rhythms
Internal Medicine
Kidneys
Laboratory Medicine
Light effects
Melatonin
Ontogeny
Pathology
Skeletal muscle
Vitamin E
early postnatal ontogeny
Wistar rats
light deprivation
α-tocopherol
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Summary:We studied the effect of long-term light deprivation which began at different stages of ontogeny on the content of α-tocopherol in rats during the first 3 months of postnatal development. In the offspring postnatally exposed to constant darkness, the level of α-tocopherol in the liver, kidneys, heart, skeletal muscles, and lungs was significantly decreased at the early stages of postnatal ontogeny (2 weeks and 1 month). In rats kept under constant darkness after birth, the content of α-tocopherol in the lungs was also reduced at the age of 1 month. The modulating effect of light deprivation on the level of α-tocopherol can be associated both with the impact of disturbed circadian rhythms and with increased content of melatonin in the body.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05054-1