Targeting GABA signalling for cancer treatment

Synthesis of the neurotransmitter GABA (γ-aminobutyric acid) by glutamate decarboxylase (GAD) normally occurs in neurons. A study now shows that ectopic expression of GAD leads to GABA accumulation, enhanced tumour cell proliferation and immunosuppression, and blocking GABA signalling improves the a...

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Bibliographic Details
Published inNature cell biology Vol. 24; no. 2; pp. 131 - 132
Main Authors Huang, Wei, Cao, Lei
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.02.2022
Nature Publishing Group
Subjects
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692/699/67/327
Anticancer properties
Biology
Biomedical and Life Sciences
Brain cancer
Cancer Research
Cancer therapies
Cell Biology
Cell Communication
Cell growth
Cell proliferation
Colorectal cancer
Dendritic cells
Developmental Biology
Ectopic expression
gamma-Aminobutyric Acid
Gene expression
Glutamate decarboxylase
Humans
Immunocompetence
Immunosuppression
Immunotherapy
Kinases
Life Sciences
Lymphocytes
Medical prognosis
Metastasis
Neoplasms - drug therapy
Neoplasms - genetics
Neurotransmitters
News & Views
news-and-views
Patients
Signal Transduction
Signaling
Stem Cells
Tumorigenesis
Tumors
γ-Aminobutyric acid
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Summary:Synthesis of the neurotransmitter GABA (γ-aminobutyric acid) by glutamate decarboxylase (GAD) normally occurs in neurons. A study now shows that ectopic expression of GAD leads to GABA accumulation, enhanced tumour cell proliferation and immunosuppression, and blocking GABA signalling improves the anti-tumour efficacy of immunotherapy.
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SourceType-Scholarly Journals-1
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ObjectType-Commentary-3
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ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-021-00839-y