Two are not enough: synthetic strategies and applications of unnatural base pairs

Nucleic acid chemistry is a rapidly evolving field, and the need for novel nucleotide modifications and artificial nucleotide building blocks for diagnostic and therapeutic use, material science or for studying cellular processes continues unabated. This review focusses on the development and applic...

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Published inBiological chemistry Vol. 404; no. 10; pp. 883 - 896
Main Authors Dörrenhaus, Robert, Wagner, Philip K., Kath-Schorr, Stephanie
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 26.09.2023
Walter de Gruyter GmbH
Subjects
Base pairs
Bats
Crystal structure
DNA polymerase
expanded genetic alphabet
glycosidic bond
Hydrogen
Information storage
Nucleic acids
nucleotide modification
Nucleotides
RNA
unnatural base pairs
expanded genetic alphabet
RNA
glycosidic bond
nucleotide modification
unnatural base pairs
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Summary:Nucleic acid chemistry is a rapidly evolving field, and the need for novel nucleotide modifications and artificial nucleotide building blocks for diagnostic and therapeutic use, material science or for studying cellular processes continues unabated. This review focusses on the development and application of unnatural base pairs as part of an expanded genetic alphabet. Not only recent developments in “nature-like” artificial base pairs are presented, but also current synthetic methods to get access to C-glycosidic nucleotides. Wide-ranging viability in synthesis is a prerequisite for the successful use of unnatural base pairs in a broader spectrum and will be discussed.
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ISSN:1431-6730
1437-4315
1437-4315
DOI:10.1515/hsz-2023-0169