Diagnostic performance of magnetic resonance imaging–based machine learning in Alzheimer’s disease detection: a meta-analysis
Purpose Advanced machine learning (ML) algorithms can assist rapid medical image recognition and realize automatic, efficient, noninvasive, and convenient diagnosis. We aim to further evaluate the diagnostic performance of ML to distinguish patients with probable Alzheimer’s disease (AD) from normal...
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Published in | Neuroradiology Vol. 65; no. 3; pp. 513 - 527 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.03.2023
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
Advanced machine learning (ML) algorithms can assist rapid medical image recognition and realize automatic, efficient, noninvasive, and convenient diagnosis. We aim to further evaluate the diagnostic performance of ML to distinguish patients with probable Alzheimer’s disease (AD) from normal older adults based on structural magnetic resonance imaging (MRI).
Methods
The Medline, Embase, and Cochrane Library databases were searched for relevant literature published up until July 2021. We used the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool and Checklist for Artificial Intelligence in Medical Imaging (CLAIM) to evaluate all included studies’ quality and potential bias. Random-effects models were used to calculate pooled sensitivity and specificity, and the Deeks’ test was used to assess publication bias.
Results
We included 24 models based on different brain features extracted by ML algorithms in 19 papers. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the summary receiver operating characteristic curve for ML in detecting AD were 0.85 (95%CI 0.81–0.89), 0.88 (95%CI 0.84–0.91), 7.15 (95%CI 5.40–9.47), 0.17 (95%CI 0.12–0.22), 43.34 (95%CI 26.89–69.84), and 0.93 (95%CI 0.91–0.95).
Conclusion
ML using structural MRI data performed well in diagnosing probable AD patients and normal elderly. However, more high-quality, large-scale prospective studies are needed to further enhance the reliability and generalizability of ML for clinical applications before it can be introduced into clinical practice. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0028-3940 1432-1920 |
DOI: | 10.1007/s00234-022-03098-2 |