Non-contrast CT-based radiomic signature for screening thoracic aortic dissections: a multicenter study
Objective To develop a non-contrast CT-based radiomic signature to effectively screen for thoracic aortic dissections (ADs). Methods We retrospectively enrolled 378 patients who underwent non-contrast chest CT scans along with CT angiography or MRI from 4 medical centers. The training and validation...
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Published in | European radiology Vol. 31; no. 9; pp. 7067 - 7076 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.09.2021
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Objective
To develop a non-contrast CT-based radiomic signature to effectively screen for thoracic aortic dissections (ADs).
Methods
We retrospectively enrolled 378 patients who underwent non-contrast chest CT scans along with CT angiography or MRI from 4 medical centers. The training and validation sets were from 3 centers, while the external test set was from a 4th center. Radiomic features were extracted from non-contrast CT images. The radiomic signature was created on the basis of selected features by a logistic regression algorithm. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve, accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were conducted to assess the predictive ability of radiomic signature.
Results
The radiomic signature demonstrated AUCs of 0.91 (95% confidence interval [CI], 0.86–0.95) in the training set, 0.92 (95% CI, 0.86–0.98) in the validation set, and 0.90 (95% CI, 0.82–0.98) in the external test set. The predicted diagnosis was in good agreement with the probability of thoracic AD. In the external test group, the diagnostic accuracy, sensitivity, specificity, PPV, and NPV were 90.5%, 85.7%, 91.7%, 70.6%, and 96.5%, respectively.
Conclusions
A radiomic signature based on non-contrast CT images can effectively predict thoracic ADs. This method may serve as a potential screening tool for thoracic ADs.
Key Points
• The non-contrast CT-based radiomic signature can effectively predict the thoracic aortic dissections.
• This radiomic signature shows better predictive performance compared to the current clinical model.
• This prediction method may be a potential tool for screening thoracic aortic dissections. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0938-7994 1432-1084 |
DOI: | 10.1007/s00330-021-07768-2 |