Change in Adipokines and Gastrointestinal Hormones After Bariatric Surgery: a Meta-analysis

• Published in: Obesity surgery Vol. 33; no. 3; pp. 789 - 806
• Main Authors: Huang, Jiayun, Chen, Yanya, Wang, Xuan, Wang, Cunchuan, Yang, Jingge, Guan, Bingsheng
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2023; Springer Nature B.V
• Subjects: Adipokines; Adiponectin; Bariatric Surgery - methods; C-Reactive Protein; Cytokines; Gastrointestinal Hormones; Gastrointestinal surgery; Ghrelin - metabolism; Glucagon-Like Peptide 1 - metabolism; Humans; Interleukin-6; Leptin; Medicine; Medicine & Public Health; Meta-analysis; Obesity, Morbid - surgery; Original Contributions; Peptide YY - metabolism; Peptides; Surgery; Tumor Necrosis Factor-alpha; Obesity; Gastrointestinal hormone; Adipokine; Bariatric surgery; Meta-analysis
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-022-06444-8

Purpose The study aimed to perform a meta-analysis about the change in adipokines and gastrointestinal hormones after bariatric surgery in patients with obesity. Materials and Methods We searched the Cochrane Central Register of Controlled Trials, EMBASE, and PubMed for related articles and used Review Manager 5.4 for data aggregation. Sensitivity and subgroup analysis were also conducted when feasible. Results As a result, 95 articles involving 6232 patients were included in the meta-analysis. After bariatric surgery, the levels of leptin, ghrelin, C-reactive protein (CRP), interleukin-6 (IL-6), high-sensitivity C-reactive protein (Hs-CRP), tumor necrosis, factor-α (TNF-α), and interleukin-1β (IL-1β) reduced, while adiponectin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) levels increased significantly. Subgroup analysis indicated that there was a more significant reduction in leptin level with a longer follow-up time. OAGB had a greater effect on increasing adiponectin level compared with other procedures. SG procedure would bring about reduced ghrelin, while BPD resulted in increased ghrelin. Meta-regression analysis found that publication year, study design, number of patients, preoperative age, preoperative BMI, and quality assessment score were not significantly related to change in leptin, adiponectin, and ghrelin levels. Conclusion Bariatric surgery was associated with a significant decrease in leptin, ghrelin, CRP, IL-6, Hs-CRP, TNF-α, and IL-1β, as well as increase in adiponectin, GLP-1, and PYY levels. Graphical Abstract