Quality of life in first episode psychosis: a cluster analytic approach

• Published in: Quality of life research Vol. 31; no. 6; pp. 1807 - 1817
• Main Authors: Liao, Z., Allott, K., Anderson, J. F. I., Killackey, E., Cotton, S. M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2022; Springer Nature B.V
• Subjects: Cluster analysis; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Psychosis; Public Health; Quality of life; Quality of Life Research; Sociology; First episode psychosis; Cluster analysis; Depression; Quality of life
• ISSN: 0962-9343; 1573-2649
• DOI: 10.1007/s11136-021-03014-w

Purpose Quality of life is increasingly recognised as an important outcome for young people with first episode psychosis (FEP). The first aim was to determine whether distinct homogenous subgroups of young people with FEP could be delineated based on profiles on quality of life domains (Physical Health, Psychological, Social relationships and Environmental). The second aim was to examine the discriminant validity of these subgroups with respect to demographic, functioning and clinical features of FEP. Method Quality of life, demographic characteristics, clinical characteristics, cognition and functioning were assessed in 145 people with FEP. Cluster analysis using Ward’s methods and Squared Euclidean Distance with a k -means verification were employed to identify subgroups with homogenous quality of life profiles. The clusters were externally validated using multinomial logistic regressions. Results Three distinct quality of life profiles were identified: one with good quality of life across all domains (30%), one with poor quality of life particularly in Psychological and Social relationships domains (28%), and one ‘intermediate’ group with comparatively low Psychological quality of life (42%). Depression, semantic verbal fluency, social inclusion and social/occupational functioning showed associations with group membership. Conclusion Our results suggest the potential of maintaining relatively good quality of life despite the experience of FEP. Future research on interventions to improve quality of life may consider the potential of addressing depression, social inclusion and social/occupational functioning.