Palladium-catalysed cross-coupling of organosilicon reagents
The palladium catalysed cross-coupling of organosilicon reagents with organo halides and pseudo-halides has developed over the past 30 years into an efficient and attractive carboncarbon bond forming strategy. Extensive research within this field to expand and diversify on the scope of the organosil...
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| Published in | Chemical Society reviews Vol. 41; no. 5; pp. 1845 - 1866 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
07.03.2012
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| Online Access | Get full text |
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| Summary: | The palladium catalysed cross-coupling of organosilicon reagents with organo halides and pseudo-halides has developed over the past 30 years into an efficient and attractive carboncarbon bond forming strategy. Extensive research within this field to expand and diversify on the scope of the organosilicon coupling reaction will continue to promote its use in the synthesis of biologically and pharmaceutically important organic molecules. The recent advances made within this area are explored in this
critical review
(199 references).
This critical review highlights recent advances in cross-coupling using organosilicon reagents with organo halides and pseudo-halides. |
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| Bibliography: | Hannah Sore attended the University of Durham for her undergraduate chemistry degree. After working as a medicinal chemist at Millennium Pharmaceuticals and Astex Therapeutics she started a PhD at the University of Cambridge under the supervision of Dr David Spring. Her studies focused on the development of new silicon-based cross-coupling methodologies. Hannah now works as a Research Analyst at Frost & Sullivan. Dr David Spring is currently a Reader at the University of Cambridge within the Chemistry Department. He received his DPhil (1998) at Oxford University under Sir Jack Baldwin. He then worked as a Wellcome Trust Postdoctoral Fellow at Harvard University with Stuart Schreiber (19992001), after which he joined the faculty at the University of Cambridge. His research programme is focused on synthetic chemistry and chemical biology. Warren Galloway was born in Dundee, Scotland and attended the University of Cambridge for his undergraduate chemistry degree. He stayed at Cambridge for his PhD studies under the supervision of Dr David Spring, where he worked on the development of strategies for diversity-oriented synthesis. Warren received his PhD in 2008 and is currently a postdoctoral research assistant for Dr David Spring, working on the design and synthesis of small molecule modulators of biological processes. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c1cs15181a |