B cells regulate hematopoietic stem cells via cholinergic signaling

B-cell-derived acetylcholine initiates a circuit that prompts bone marrow stromal cells to secrete factors that restrain the blood-forming activity of hematopoietic stem cells in response to cardiovascular dysfunction.

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Bibliographic Details
Published inNature immunology Vol. 23; no. 4; pp. 476 - 478
Main Authors Patel, Sweta B., Pietras, Eric M.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2022
Nature Publishing Group
Subjects
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B-Lymphocytes
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cholinergic Agents
Hematopoietic stem cells
Hematopoietic Stem Cells - physiology
Immunology
Infectious Diseases
Lymphocytes B
News & Views
news-and-views
Signal Transduction
Stem cells
Stromal cells
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Summary:B-cell-derived acetylcholine initiates a circuit that prompts bone marrow stromal cells to secrete factors that restrain the blood-forming activity of hematopoietic stem cells in response to cardiovascular dysfunction.
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ISSN:1529-2908
1529-2916
DOI:10.1038/s41590-022-01172-8