Effects of pre-dialysis resistance training on sarcopenia, inflammatory profile, and anemia biomarkers in older community-dwelling patients with chronic kidney disease: a randomized controlled trial

• Published in: International urology and nephrology Vol. 53; no. 10; pp. 2137 - 2147
• Main Authors: Gadelha, André Bonadias, Cesari, Matteo, Corrêa, Hugo Luca, Neves, Rodrigo Vanerson Passos, Sousa, Caio Victor, Deus, Lysleine Alves, Souza, Michel Kendy, Reis, Andrea Lucena, Moraes, Milton Rocha, Prestes, Jonato, Simões, Herbert Gustavo, Andrade, Rosangela Vieira, Melo, Gislane Ferreira, Rosa, Thiago Santos
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.10.2021; Springer Nature B.V
• Subjects: Aged; Anemia; Anemia - blood; Anemia - complications; Biomarkers; Biomarkers - blood; Dialysis; Dual energy X-ray absorptiometry; Female; Ferritin; Hemodialysis; Hepcidin; Humans; Independent Living; Inflammation; Inflammation - blood; Inflammation - complications; Interleukin 10; Interleukin 6; Iron; Kidney diseases; Male; Medicine; Medicine & Public Health; Middle Aged; Mortality; Nephrology; Nephrology - Original Paper; Patients; Physical training; Renal Dialysis; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - therapy; Resistance Training; Sarcopenia; Sarcopenia - blood; Sarcopenia - complications; Sarcopenia - therapy; Strength training; Time Factors; Tumor necrosis factor-α; Urology; Aging; Inflammatory profile; Chronic kidney disease; Muscle strength; Mortality
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-021-02799-6

Background Sarcopenia and chronic kidney disease (CKD) have been associated with negative outcomes in older people, including inflammatory profile and anemia biomarkers. Aims To investigate the effects of pre-dialysis resistance training (RT) on sarcopenia, inflammatory profile, and anemia biomarkers in older patients with CKD. Methods A total of 107 patients with CKD (65.4 ± 3.7 years) were randomly allocated into four groups: sarcopenic RT ( n  = 37), non-sarcopenic RT ( n  = 20), sarcopenic control ( n  = 28), and non-sarcopenic control ( n  = 22). DXA and handgrip strength were used to classify sarcopenia according to EWGSOP-2. Treatment groups underwent a 24-week intervention with RT before each dialysis session, three times per week. Blood sample analysis for ferritin, hepcidin, iron availability, and inflammatory profile (TNFα, IL-6, and IL-10) was conducted. All-cause mortality was recorded over 5 years. Results Sarcopenic RT group increased iron availability after the intervention, while their counterparts decreased. Ferritin and hepcidin significantly decreased in sarcopenic RT group. RT elicited a reduction in both TNFα and IL-6, while increasing IL-10 in both intervention groups. The rate of sarcopenic subjects substantially decreased after the intervention period (from 37 to 17 in the RT group; p  = 0.01). The proportion of deaths was higher ( P  = 0.033) for sarcopenic subjects (Controls 35.7% vs RT 29.7%) when compared to non-sarcopenic subjects (Controls 18% vs RT 10%). The proportion of deaths decreased according to the randomization group (X2 = 8.704; P  < 0.1). Conclusions The 24-week RT intervention elicited a better sarcopenia status, better inflammatory profile, and improved anemia biomarkers. Sarcopenia was associated with higher mortality rate in older patients with CKD.