FVII gene R353Q polymorphism and coronary heart disease: a meta-analysis including 3258 subjects

• Published in: Journal of thrombosis and thrombolysis Vol. 52; no. 1; pp. 324 - 330
• Main Authors: Li, Yan-yan, Wang, Hui, Zhang, Yang-yang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2021; Springer Nature B.V
• Subjects: Alleles; Asians - genetics; Cardiology; Cardiovascular disease; Coagulation factor VII; Coagulation factors; Coronary artery disease; Coronary Disease - genetics; Factor VII - genetics; Gene polymorphism; Heart diseases; Hematology; Humans; Medicine; Medicine & Public Health; Meta-analysis; Polymorphism; Polymorphism, Genetic; Population genetics; R353Q; Coagulation factor VII; Coronary heart disease; Polymorphism
• ISSN: 0929-5305; 1573-742X; 1573-742X
• DOI: 10.1007/s11239-020-02363-6

The coagulation factor VII ( FVII ) gene R353Q polymorphism is suggested to be relevant to the coronary heart disease (CHD) susceptibility. However, the results of separate studies are not consistent with one another. A meta-analysis including 3258 participants from nine studies was conducted to investigate the relationship between the FVII gene R353Q polymorphism and the CHD in the Chinese population. The fixed-effect models were used to assess the pooled odds ratios (ORs) and their corresponding 95% confidence intervals. A significant association was observed between the FVII gene R353Q polymorphism and the CHD in the Chinese population under allelic (OR 1.34, 95% CI 1.10–1.65, P  = 0.004), dominant (OR 0.68, 95% CI 0.55–0.85, P  = 0.0006), and heterozygous (OR 0.68, 95% CI 0.55–0.85, P  = 0.0007) genetic models. The FVII gene R353Q polymorphism was significantly correlated with the CHD susceptibility in the Chinese population. Persons with the R allele of the FVII gene R353Q polymorphism might have greater CHD risk than others.