Extent of resection and survival for oligodendroglioma: a U.S. population-based study

• Published in: Journal of neuro-oncology Vol. 144; no. 3; pp. 591 - 601
• Main Authors: Kinslow, Connor J., Garton, Andrew L.A., Rae, Ali I., Marcus, Logan P., Adams, Christopher M., McKhann, Guy M., Sisti, Michael B., Connolly, E. Sander, Bruce, Jeffrey N., Neugut, Alfred I., Sonabend, Adam M., Canoll, Peter, Cheng, Simon K., Wang, Tony J. C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2019; Springer Nature B.V
• Subjects: Adolescent; Adult; Biopsy; Brain cancer; Brain Neoplasms - epidemiology; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Child; Child, Preschool; Clinical Study; Epidemiology; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; Medical prognosis; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neurosurgical Procedures - methods; Neurosurgical Procedures - mortality; Oligodendroglioma; Oligodendroglioma - epidemiology; Oligodendroglioma - mortality; Oligodendroglioma - pathology; Oligodendroglioma - surgery; Oncology; Population studies; Population-based studies; Prognosis; Retrospective Studies; Surgery; Survival; Survival Rate; Tumors; United States - epidemiology; Young Adult; United States; United States > US; Extent of resection; Gross-total resection; Surgery; Oligodendroglioma
• ISSN: 0167-594X; 1573-7373
• DOI: 10.1007/s11060-019-03261-5

Background National guidelines recommend maximal safe resection of low-grade and high-grade oligodendrogliomas. However, there is no level 1 evidence to support these guidelines, and recent retrospective studies on the topic have yielded mixed results. Objective To assess the association between extent of resection (EOR) and survival for oligodendrogliomas in the general U.S. population. Methods Cases diagnosed between 2004 and 2013 were selected from the Surveillance, Epidemiology, and End-Results (SEER) Program and retrospectively analyzed for treatment, prognostic factors, and survival times. Cases that did not undergo tumor de-bulking surgery (e.g. no surgery or biopsy alone) were compared to subtotal resection (resection) and gross-total resection (GTR). The primary end-points were overall survival (OS) and cause-specific survival (CSS). An external validation cohort with 1p/19q-codeleted tumors was creating using the TCGA and GSE16011 datasets. Results 3135 Cases were included in the final analysis. The 75% survival time (75ST) and 5-year survival rates were 47 months and 70.8%, respectively. Subtotal resection (STR, 75ST = 50 months) and GTR (75ST = 61 months) were associated with improved survival times compared to cases that did not undergo surgical debulking (75ST = 20 months, P  < 0.001 for both), with reduced hazard ratios (HRs) after controlling for other factors (HR 0.81 [0.68–0.97] and HR 0.65 [0.54–0.79], respectively). GTR was associated with improved OS in both low-grade and anaplastic oligodendroglioma subgroups (HR 0.74 [0.58–0.95], HR 0.60 [0.44–0.82], respectively) while STR fell short of significance in the subgroup analysis. All findings were corroborated by multivariable analysis of CSS and externally validated in a cohort of patients with 1p19q-codeleted tumors. Conclusion Greater EOR is associated with improved survival in oligodendrogliomas. Our findings in this U.S. population-based cohort support national guidelines.