Supporting Evidence of Human Enteric Nervous System Adult Neurogenesis: Presence of Primary Cilia and Adult Neurogenesis Markers

Adult neurogenesis has been profusely studied in central nervous system. However, its presence in enteric nervous system remains elusive although it has been recently demonstrated in mice and intimately linked to glial cells. Moreover, primary cilium is an important organelle in central adult neurog...

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Published inCellular and molecular neurobiology Vol. 42; no. 2; pp. 473 - 481
Main Authors Iruzubieta, Pablo, Cantarero, Irene, Monzón, Marta, Lahoz, Manuel, Junquera, Concepción
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2022
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell division
Central nervous system
Cilia
Enteric nervous system
Enteric Nervous System - metabolism
Glial cells
Humans
Interstitial cells
Interstitial cells of Cajal
Mice
Nervous system
Neural stem cells
Neurobiology
Neurogenesis
Neurogenesis - physiology
Neuroglia
Neurons - metabolism
Neurosciences
Original Research
Stem cell transplantation
Stem cells
Interstitial cell of cajal
Transmission electron microscopy
Primary cilia
Adult neurogenesis
Enteric glia
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Summary:Adult neurogenesis has been profusely studied in central nervous system. However, its presence in enteric nervous system remains elusive although it has been recently demonstrated in mice and intimately linked to glial cells. Moreover, primary cilium is an important organelle in central adult neurogenesis. In the present study, we analysed some parallelisms between central and enteric nervous system (ENS) in humans based on ultrastructural and immunohistochemical techniques. Thus, we described the presence of primary cilia in some subtypes of glial cells and Interstitial Cells of Cajal (ICCs) and we performed 3-D reconstructions to better characterise their features. Besides, we studied the expression of several adult neurogenesis-related proteins. Immature neuron markers were found in human ENS, supporting the existence of adult neurogenesis. However, only ICCs showed proliferation markers. Hence, we propose a new paradigm where ICCs would constitute the original neural stem cells which, through asymmetrical cell division, would generate the new-born neurons.
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ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-020-01017-8