Prototype positron emission tomography insert with electro-optical signal transmission for simultaneous operation with MRI

• Published in: Physics in medicine & biology Vol. 60; no. 9; pp. 3459 - 3478
• Main Authors: Olcott, Peter, Kim, Ealgoo, Hong, Keyjo, Lee, Brian J, Grant, Alexander M, Chang, Chen-Ming, Glover, Gary, Levin, Craig S
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 07.05.2015
• Subjects: Alzheimer's diagnosis; detectors; electro-optical; magnetic resonance imaging; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Multimodal Imaging - instrumentation; Multimodal Imaging - methods; PET; PET/MRI; positron emission tomography; Positron-Emission Tomography - instrumentation; Positron-Emission Tomography - methods
• ISSN: 0031-9155; 1361-6560; 1361-6560
• DOI: 10.1088/0031-9155/60/9/3459

The simultaneous acquisition of PET and MRI data shows promise to provide powerful capabilities to study disease processes in human subjects, guide the development of novel treatments, and monitor therapy response and disease progression. A brain-size PET detector ring insert for an MRI system is being developed that, if successful, can be inserted into any existing MRI system to enable simultaneous PET and MRI images of the brain to be acquired without mutual interference. The PET insert uses electro-optical coupling to relay all the signals from the PET detectors out of the MRI system using analog modulated lasers coupled to fiber optics. Because the fibers use light instead of electrical signals, the PET detector can be electrically decoupled from the MRI making it partially transmissive to the RF field of the MRI. The SiPM devices and low power lasers were powered using non-magnetic MRI compatible batteries. Also, the number of laser-fiber channels in the system was reduced using techniques adapted from the field of compressed sensing. Using the fact that incoming PET data is sparse in time and space, electronic circuits implementing constant weight codes uniquely encode the detector signals in order to reduce the number of electro-optical readout channels by 8-fold. Two out of a total of sixteen electro-optical detector modules have been built and tested with the entire RF-shielded detector gantry for the PET ring insert. The two detectors have been tested outside and inside of a 3T MRI system to study mutual interference effects and simultaneous performance with MRI. Preliminary results show that the PET insert is feasible for high resolution simultaneous PET/MRI imaging for applications in the brain.