Individual vs. combined imaging modalities for diagnosing neovascular central serous chorioretinopathy

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 261; no. 5; pp. 1267 - 1273
• Main Authors: Borrelli, Enrico, Viganò, Chiara, Battista, Marco, Sacconi, Riccardo, Senni, Carlotta, Querques, Lea, Grosso, Domenico, Bandello, Francesco, Querques, Giuseppe
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2023; Springer Nature B.V
• Subjects: Accuracy; Angiography; Central Serous Chorioretinopathy - diagnosis; Choroidal Neovascularization - diagnosis; Fluorescein Angiography - methods; Humans; Indocyanine Green - pharmacology; Medical imaging; Medicine; Medicine & Public Health; Ophthalmology; Retina; Retinal Disorders; Retrospective Studies; Tomography, Optical Coherence - methods; Vascularization; Indocyanine green angiography; Macula; Choroidal neovascularization; Optical coherence tomography; Optical coherence tomography angiography; Central serous chorioretinopathy; Double layer sign
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-022-05924-y

Purpose To assess the diagnostic accuracy of individual and combined imaging modalities compared with multimodal imaging for the detection of choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). Methods We analyzed patients with CSC with and without CNV who had indocyanine green angiography (ICGA), structural optical coherence tomography (OCT), and OCT angiography (OCTA) obtained on the same day. The presence of CNV was determined using multimodal imaging by a senior retina specialist (i.e., diagnostic reference). Individual and combined (i.e., ICGA + structural OCT) imaging modalities were then graded by two expert readers for the presence of CNV. Sensitivity, specificity, positive (PPV), and negative (NPV) predictive values were computed for individual and combined imaging modalities relative to the diagnostic reference. Results CNV was detected in 17 eyes in 17 out of 33 CSC patients according to the reference standard. Using ICGA, the identification of CNV had a sensitivity of 66.7%, specificity of 66.7%, PPV of 70.6%, and NPV of 62.5%. Structural OCT had the following diagnostic accuracy values: 83.3% of sensitivity, 53.3% of specificity, 68.1% of PPV, and 72.7% of NPV. Using OCTA, CNV was graded to be present with a sensitivity of 77.8%, specificity of 86.7%, PPV of 87.5%, and NPV of 76.5%. The combination of ICGA and structural OCT granted the identification of CNV with a sensitivity of 83.3%, specificity of 86.7%, PPV of 88.2%, and NPV of 81.3%. Conclusions OCTA has an elevated diagnostic accuracy in identifying CSC-associated CNV, though a combination of ICGA and structural OCT has a comparable diagnostic efficiency.