Preliminary Exploration of MAGE-B1, -B4, -B5, and -B10 mRNA Expression in Canine Mammary Tumors in Dogs

The melanoma-associated antigen gene (MAGE) is a key target in cancer immunotherapy. Given the potential of MAGE-B genes in veterinary immunotherapy for canine mammary tumors (CMTs), this study investigated the mRNA expression of MAGE-B1, -B4, -B5, and -B10 in CMT tissues and cells from dogs. Quanti...

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Published inAnimals (Basel) Vol. 15; no. 7; p. 910
Main Authors Srisawat, Wanwisa, Koonyosying, Pongpisid, Muenthaisong, Anucha, Sangkakam, Kanokwan, Varinrak, Thanya, Sthitmatee, Nattawooti
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.03.2025
Subjects
Antigens
Breast cancer
Cancer
Cancer therapies
Cancer vaccines
canine mammary tumors
Care and treatment
Cell culture
Chemical tests and reagents
Chemotherapy
Chromosomes
Cloning
DNA methylation
Dogs
Enzymes
Epigenetics
Gene expression
Genes
Genetic aspects
Immunotherapy
Medical research
Medicine, Experimental
Melanoma
melanoma-associated antigen-B
Messenger RNA
Metastasis
Methylation
mRNA expression
Penicillin
quantitative real-time PCR
Surgery
Tumors
Vaccines
Veterinary medicine
United Kingdom
Thailand
United States
Massachusetts
Chiang Mai Thailand
United Kingdom > UK
United States > US
canine mammary tumors
quantitative real-time PCR
melanoma-associated antigen-B
mRNA expression
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Abstract The melanoma-associated antigen gene (MAGE) is a key target in cancer immunotherapy. Given the potential of MAGE-B genes in veterinary immunotherapy for canine mammary tumors (CMTs), this study investigated the mRNA expression of MAGE-B1, -B4, -B5, and -B10 in CMT tissues and cells from dogs. Quantitative real-time PCR was used to analyze 28 CMT tissue samples, including 4 benign and 24 malignant tumors (13 simple carcinomas, 6 complex carcinomas, 3 carcinosarcomas, and 2 fibrosarcomas). Benign mixed tumor and complex carcinoma-type CMT cells were cultured and treated with a DNA methylase inhibitor (5-aza-2′-deoxycytidine; 5-aza-CdR) and a histone deacetylase inhibitor (Trichostatin A; TSA) under the following four conditions: (1) 5-aza-CdR for 72 h; (2) TSA for 24 h; (3) 5-aza-CdR for 48 h followed by TSA for 24 h; and (4) control. MAGE-B1 and -B4 showed the highest expression in the CMT samples (100% and 89.29%, respectively), followed by MAGE-B10 (82.14%). Carcinosarcomas and simple anaplastic carcinomas had significantly higher MAGE-B expression levels than simple tubulopapillary carcinomas (p < 0.05). 5-aza-CdR treatment increased MAGE-B expression, whereas TSA had a mild effect. Further research involving larger cohorts is needed to confirm these findings.
AbstractList Simple SummaryThe melanoma-associated antigen gene (MAGE) is an important target for cancer immunotherapy. MAGE-B genes may be involved with the tumor progression biomarkers of canine mammary tumors (CMTs) and have been used as immunotherapy target genes for cancer vaccines. Thus, this study looked at the mRNA expression of MAGE-B1, -B4, -B5, and -B10 in CMT tissues and cells from dogs. Researchers examined 28 tumor samples (4 benign and 24 malignant) using a real-time PCR technique. They also grew CMT cells and treated them with two reagents—a DNA methylation inhibitor (5-aza-2′-deoxycytidine; 5-aza-CdR) and a histone deacetylase inhibitor (Trichostatin A; TSA)—under four different conditions. The results showed that MAGE-B1 and -B4 had the highest mRNA expression in the CMT samples (100% and 89.29%), followed by MAGE-B10 (82.14%). Tumors classified as carcinosarcomas and simple anaplastic carcinomas had significantly higher MAGE-B mRNA expression levels than simple tubulopapillary carcinomas (p < 0.05). Cells treated with 5-aza-CdR showed increased MAGE-B mRNA expression, while TSA had little effect. A larger study is needed to confirm these findings and better understand MAGE-B mRNA expression patterns.
The melanoma-associated antigen gene (MAGE) is a key target in cancer immunotherapy. Given the potential of MAGE-B genes in veterinary immunotherapy for canine mammary tumors (CMTs), this study investigated the mRNA expression of MAGE-B1, -B4, -B5, and -B10 in CMT tissues and cells from dogs. Quantitative real-time PCR was used to analyze 28 CMT tissue samples, including 4 benign and 24 malignant tumors (13 simple carcinomas, 6 complex carcinomas, 3 carcinosarcomas, and 2 fibrosarcomas). Benign mixed tumor and complex carcinoma-type CMT cells were cultured and treated with a DNA methylase inhibitor (5-aza-2′-deoxycytidine; 5-aza-CdR) and a histone deacetylase inhibitor (Trichostatin A; TSA) under the following four conditions: (1) 5-aza-CdR for 72 h; (2) TSA for 24 h; (3) 5-aza-CdR for 48 h followed by TSA for 24 h; and (4) control. MAGE-B1 and -B4 showed the highest expression in the CMT samples (100% and 89.29%, respectively), followed by MAGE-B10 (82.14%). Carcinosarcomas and simple anaplastic carcinomas had significantly higher MAGE-B expression levels than simple tubulopapillary carcinomas (p < 0.05). 5-aza-CdR treatment increased MAGE-B expression, whereas TSA had a mild effect. Further research involving larger cohorts is needed to confirm these findings.
The melanoma-associated antigen gene (MAGE) is a key target in cancer immunotherapy. Given the potential of MAGE-B genes in veterinary immunotherapy for canine mammary tumors (CMTs), this study investigated the mRNA expression of MAGE-B1, -B4, -B5, and -B10 in CMT tissues and cells from dogs. Quantitative real-time PCR was used to analyze 28 CMT tissue samples, including 4 benign and 24 malignant tumors (13 simple carcinomas, 6 complex carcinomas, 3 carcinosarcomas, and 2 fibrosarcomas). Benign mixed tumor and complex carcinoma-type CMT cells were cultured and treated with a DNA methylase inhibitor (5-aza-2'-deoxycytidine; 5-aza-CdR) and a histone deacetylase inhibitor (Trichostatin A; TSA) under the following four conditions: (1) 5-aza-CdR for 72 h; (2) TSA for 24 h; (3) 5-aza-CdR for 48 h followed by TSA for 24 h; and (4) control. MAGE-B1 and -B4 showed the highest expression in the CMT samples (100% and 89.29%, respectively), followed by MAGE-B10 (82.14%). Carcinosarcomas and simple anaplastic carcinomas had significantly higher MAGE-B expression levels than simple tubulopapillary carcinomas (p < 0.05). 5-aza-CdR treatment increased MAGE-B expression, whereas TSA had a mild effect. Further research involving larger cohorts is needed to confirm these findings.The melanoma-associated antigen gene (MAGE) is a key target in cancer immunotherapy. Given the potential of MAGE-B genes in veterinary immunotherapy for canine mammary tumors (CMTs), this study investigated the mRNA expression of MAGE-B1, -B4, -B5, and -B10 in CMT tissues and cells from dogs. Quantitative real-time PCR was used to analyze 28 CMT tissue samples, including 4 benign and 24 malignant tumors (13 simple carcinomas, 6 complex carcinomas, 3 carcinosarcomas, and 2 fibrosarcomas). Benign mixed tumor and complex carcinoma-type CMT cells were cultured and treated with a DNA methylase inhibitor (5-aza-2'-deoxycytidine; 5-aza-CdR) and a histone deacetylase inhibitor (Trichostatin A; TSA) under the following four conditions: (1) 5-aza-CdR for 72 h; (2) TSA for 24 h; (3) 5-aza-CdR for 48 h followed by TSA for 24 h; and (4) control. MAGE-B1 and -B4 showed the highest expression in the CMT samples (100% and 89.29%, respectively), followed by MAGE-B10 (82.14%). Carcinosarcomas and simple anaplastic carcinomas had significantly higher MAGE-B expression levels than simple tubulopapillary carcinomas (p < 0.05). 5-aza-CdR treatment increased MAGE-B expression, whereas TSA had a mild effect. Further research involving larger cohorts is needed to confirm these findings.
The melanoma-associated antigen gene (MAGE) is a key target in cancer immunotherapy. Given the potential of MAGE-B genes in veterinary immunotherapy for canine mammary tumors (CMTs), this study investigated the mRNA expression of , , , and in CMT tissues and cells from dogs. Quantitative real-time PCR was used to analyze 28 CMT tissue samples, including 4 benign and 24 malignant tumors (13 simple carcinomas, 6 complex carcinomas, 3 carcinosarcomas, and 2 fibrosarcomas). Benign mixed tumor and complex carcinoma-type CMT cells were cultured and treated with a DNA methylase inhibitor (5-aza-2'-deoxycytidine; 5-aza-CdR) and a histone deacetylase inhibitor (Trichostatin A; TSA) under the following four conditions: (1) 5-aza-CdR for 72 h; (2) TSA for 24 h; (3) 5-aza-CdR for 48 h followed by TSA for 24 h; and (4) control. and showed the highest expression in the CMT samples (100% and 89.29%, respectively), followed by (82.14%). Carcinosarcomas and simple anaplastic carcinomas had significantly higher MAGE-B expression levels than simple tubulopapillary carcinomas ( < 0.05). 5-aza-CdR treatment increased MAGE-B expression, whereas TSA had a mild effect. Further research involving larger cohorts is needed to confirm these findings.
The melanoma-associated antigen gene (MAGE) is an important target for cancer immunotherapy. MAGE-B genes may be involved with the tumor progression biomarkers of canine mammary tumors (CMTs) and have been used as immunotherapy target genes for cancer vaccines. Thus, this study looked at the mRNA expression of MAGE-B1, -B4, -B5, and -B10 in CMT tissues and cells from dogs. Researchers examined 28 tumor samples (4 benign and 24 malignant) using a real-time PCR technique. They also grew CMT cells and treated them with two reagents—a DNA methylation inhibitor (5-aza-2′-deoxycytidine; 5-aza-CdR) and a histone deacetylase inhibitor (Trichostatin A; TSA)—under four different conditions. The results showed that MAGE-B1 and -B4 had the highest mRNA expression in the CMT samples (100% and 89.29%), followed by MAGE-B10 (82.14%). Tumors classified as carcinosarcomas and simple anaplastic carcinomas had significantly higher MAGE-B mRNA expression levels than simple tubulopapillary carcinomas (p < 0.05). Cells treated with 5-aza-CdR showed increased MAGE-B mRNA expression, while TSA had little effect. A larger study is needed to confirm these findings and better understand MAGE-B mRNA expression patterns.
Audience Academic
Author Muenthaisong, Anucha
Koonyosying, Pongpisid
Varinrak, Thanya
Srisawat, Wanwisa
Sthitmatee, Nattawooti
Sangkakam, Kanokwan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/40218304$$D View this record in MEDLINE/PubMed
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Snippet The melanoma-associated antigen gene (MAGE) is a key target in cancer immunotherapy. Given the potential of MAGE-B genes in veterinary immunotherapy for canine...
The melanoma-associated antigen gene (MAGE) is an important target for cancer immunotherapy. MAGE-B genes may be involved with the tumor progression biomarkers...
Simple SummaryThe melanoma-associated antigen gene (MAGE) is an important target for cancer immunotherapy. MAGE-B genes may be involved with the tumor...
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SubjectTerms Antigens
Breast cancer
Cancer
Cancer therapies
Cancer vaccines
canine mammary tumors
Care and treatment
Cell culture
Chemical tests and reagents
Chemotherapy
Chromosomes
Cloning
DNA methylation
Dogs
Enzymes
Epigenetics
Gene expression
Genes
Genetic aspects
Immunotherapy
Medical research
Medicine, Experimental
Melanoma
melanoma-associated antigen-B
Messenger RNA
Metastasis
Methylation
mRNA expression
Penicillin
quantitative real-time PCR
Surgery
Tumors
Vaccines
Veterinary medicine
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Title Preliminary Exploration of MAGE-B1, -B4, -B5, and -B10 mRNA Expression in Canine Mammary Tumors in Dogs
URI https://www.ncbi.nlm.nih.gov/pubmed/40218304
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