Risk stratification by combining common genetic mutations and TERT promoter methylation in papillary thyroid cancer

• Published in: Endocrine Vol. 85; no. 1; pp. 304 - 312
• Main Authors: Sang, Ye, Hu, Guanghui, Xue, Junyu, Chen, Mengke, Hong, Shubin, Liu, Rengyun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2024; Springer Nature B.V
• Subjects: Adult; Aged; Coexistence; Diabetes; DNA Methylation; Endocrinology; Female; Humanities and Social Sciences; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Metastases; Middle Aged; multidisciplinary; Mutation; Original Article; Papillary thyroid cancer; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf - genetics; Risk Assessment; Risk groups; Science; Telomerase - genetics; Thyroid cancer; Thyroid Cancer, Papillary - genetics; Thyroid Cancer, Papillary - pathology; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; Young Adult; DNA methylation; mutation; Prognosis; Papillary thyroid cancer; promoter mutation; TERT promoter mutation; BRAF mutation

Purpose Risk stratification based on somatic mutations in TERT promoter and BRAF / RAS has been well established for papillary thyroid cancer (PTC), and there is emerging evidence showed that TERT promoter methylation was frequently observed in thyroid cancer patients with adverse features. This stu...