Fovea sparing versus complete internal limiting membrane peeling for myopic traction maculopathy: a meta-analysis

• Published in: International ophthalmology Vol. 42; no. 3; pp. 765 - 773
• Main Authors: Chen, Guohai, Mao, Sihong, Tong, Yuhua, Jiang, Fangzheng, Yang, Jiasong, Li, Wensheng
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.03.2022; Springer Nature B.V
• Subjects: Acuity; Basement Membrane - surgery; Constraining; Epiretinal Membrane - diagnosis; Epiretinal Membrane - surgery; Eye; Eye (anatomy); Fovea; Humans; Macular Degeneration - complications; Medicine; Medicine & Public Health; Membranes; Meta-analysis; Myopia; Myopia, Degenerative - complications; Myopia, Degenerative - surgery; Ophthalmology; Original Paper; Peeling; Retina; Retinal detachment; Retinal Perforations - diagnosis; Retinal Perforations - surgery; Retrospective Studies; Tomography, Optical Coherence - methods; Visual acuity; Vitrectomy - methods; Internal limiting membrane peeling; Vitrectomy; Myopic traction maculopathy; Meta-analysis
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-021-02042-2

Purpose Myopic traction maculopathy (MTM) is the leading cause of visual loss in high myopia. The purpose of this study was to compare the outcomes of pars plana vitrectomy (PPV) with fovea-sparing internal limiting membrane (ILM) peeling and complete ILM peeling for MTM. Methods A comprehensive literature search was performed to find relevant studies. A meta-analysis was conducted by comparing the weighted mean differences (WMD) in the change of best-corrected visual acuity (BCVA) and central foveal thickness (CFT) from baseline and calculating the odd ratios (OR) for rates of complete reattachment (CR) and postoperative macular hole (MH) formation. Results Ten studies were selected, including 417 eyes (172 eyes in the fovea-sparing ILM peeling group (FSIP) and 245 eyes in complete ILM peeling group (CIP)). There was no significant difference in terms of mean change in CFT from baseline and the rate of CR(WMD = 3.53, 95% CI, −25.56 to 32.63, P  = 0.81, and OR = 1.41, 95% CI, 0.81 to 2.44, P  = 0.22). FSIP was superior to CIP in terms of mean change of logMAR BCVA post operation (WMD = −0.09, 95% CI, −0.15 to −0.03, P  = 0.003), and associated with a significantly lower frequency of postoperative MH formation (OR = 0.19, 95% CI, 0.07 to 0.50, P  = 0.0008). Conclusion FSIP resulted in similar anatomic outcomes compared to CIP, but resulted in better visual acuity and lower rates of postoperative MH development.