The worldwide prevalence of latent autoimmune diabetes of adults among adult-onset diabetic individuals: a systematic review and meta-analysis

• Published in: Endocrine Vol. 82; no. 1; pp. 28 - 41
• Main Authors: Ramu, Deepika, Ramaswamy, Selvaraj, Rao, Suresh, Paul, Solomon F. D.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2023; Springer Nature B.V
• Subjects: Autoimmune diseases; Diabetes; Diabetes mellitus (insulin dependent); Endocrinology; Humanities and Social Sciences; Internal Medicine; Medicine; Medicine & Public Health; Meta- Analysis; multidisciplinary; Science; Statistical analysis; Systematic review; Bahrain; United Arab Emirates; Type 2 diabetes; Prevalence; Latent autoimmune diabetes of adults; GAD65; Meta-analysis; International Diabetes Federation
• ISSN: 1559-0100; 1355-008X; 1559-0100
• DOI: 10.1007/s12020-023-03424-5

Purpose The actual global burden of Latent Autoimmune Diabetes of Adults (LADA) remains unknown even though its prevalence is almost equal to the type 1 form of diabetes. Hence the present systematic review and meta-analysis were performed to estimate the prevalence of LADA among diabetic individuals using the studies published at global levels. Methods A comprehensive literature revival was performed to identify articles on the prevalence of LADA published till 2023. The prevalence estimates were calculated using DerSimonian and Laird random-effects models with a heterogeneity measure by Cochrane Q and I 2 statistics. Publication bias was assessed by the Doi plot and Luis Furuya-Kanamori asymmetry index (LFKindex). P  < 0.05 was considered statistically significant. Results The overall pooled prevalence of LADA obtained from a total of 51,725 diabetic individuals was found to be 8.9% (95%CI 7.5–10.4, P  < 0.001) with a prevalence range of 2.3% in to 18.9% in United Arab Emirates and Bahrain respectively. Subgroup analysis of LADA in the context of the IDF geographic regions showed a higher prevalence in North America (13.5%), 9.5% in Middle East and North Africa, 9.4% in Africa, 9.2% in South East Asia, 8.3% in Western Pacific and the lowest prevalence of 7.0% in Europe. Conclusion The Meta-analysis revealed a worldwide prevalence of LADA as 8.9%, with the highest prevalence in Bahrain and the lowest in United Arab Emirates. Further, the higher prevalence in some IDF regions and the inconsistent association between socioeconomic status and LADA recommend more research in the future.