Adaptation of Optokinetic Reflex by Training with Different Frequency and Amplitude

• Published in: Journal of integrative neuroscience Vol. 21; no. 5; p. 131
• Main Authors: Pham, Ngoc Chien, Kim, Yong Gyu, Kim, Sang Jeong, Kim, Chang-Hee
• Format: Journal Article
• Language: English
• Published: IMR Press 22.07.2022
• Subjects: adaptation; cerebellum; motor learning; optokinetic reflex; training paradigm
• ISSN: 0219-6352; 1757-448X
• DOI: 10.31083/j.jin2105131

BACKGROUNDAlthough the occurrence of optokinetic reflex (OKR) adaptation after OKR training is well established, the dynamic properties of OKR adaptation has not been fully studied. This study aimed to examine the difference in the amount of OKR adaptation according to OKR training protocols which have different frequency or amplitude of drum oscillation. METHODSUsing C57BL/6N male mice, we induced OKR adaptation by 3 different categories of learning paradigm as follows: (1) Optokinetic drum oscillation for 60 min with same amplitude and different frequency. (2) Optokinetic drum oscillation for 60 min with same frequency and different amplitude. (3) Training with serial combination of different frequency or amplitude. RESULTSThe results show that the amount of OKR adaptation was greater after OKR training with lower frequency or amplitude than that with higher frequency or amplitude. CONCLUSIONSThis finding may suggest that the retinal slip signal with lower-velocity OKR stimulation serves as more precise instructive signal for learning, leading to induction of more efficient training effect. Another interesting finding was that the OKR gain increase tended to be greater after training composed of sequential combination of decreasing frequency or amplitude than that composed of sequential combination of increasing frequency or amplitude. Furthermore, the OKR training with high frequency or amplitude eliminated a part of learning effects which have already formed by previous training. We postulate that the stimulation during training with high frequency or amplitude may implement a disturbing instruction for OKR learning when it is conducted in mice with increased OKR gain after previous OKR training.