Dual ligand engagement for noncanonical inflammasome activation

The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.

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Published inNature immunology Vol. 23; no. 5; pp. 651 - 653
Main Authors Yang, Zhang-Hua, Han, Jiahuai
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.05.2022
Nature Publishing Group
Subjects
631/250/254
631/250/256/2177
631/250/262
Acidification
Bacteria
Bacterial infections
Biomedical and Life Sciences
Biomedicine
Cancer
Caspase 1
Caspase-11
E coli
Gram-negative bacteria
Gram-positive bacteria
Immunology
Immunotherapy
Infections
Infectious Diseases
Inflammasomes
Interleukin-1beta
Ligands
Lipopolysaccharides
mRNA
News & Views
news-and-views
NLR Family, Pyrin Domain-Containing 3 Protein
Virulence
Online AccessGet full text

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Abstract The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.
AbstractList The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.
Author Han, Jiahuai
Yang, Zhang-Hua
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  organization: Research Unit of Cellular Stress of Chinese Academy of Medical Sciences, Cancer Research Center of Xiamen University, School of Medicine, Xiamen University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35487984$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_3390_ijms231710124
crossref_primary_10_1016_j_ab_2025_115768
crossref_primary_10_2139_ssrn_4160337
crossref_primary_10_1016_j_jinorgbio_2022_112032
crossref_primary_10_2174_0109298673289984231127062528
Cites_doi 10.1016/j.mam.2020.100924
10.1016/j.isci.2020.101612
10.1038/nature15541
10.1038/nature15514
10.1038/cr.2015.139
10.1126/science.1240988
10.1038/nature10072
10.1038/nature04517
10.1038/s41590-022-01192-4
10.1038/nature10558
10.1126/science.1240248
10.1038/nature13683
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Snippet The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows...
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SubjectTerms 631/250/254
631/250/256/2177
631/250/262
Acidification
Bacteria
Bacterial infections
Biomedical and Life Sciences
Biomedicine
Cancer
Caspase 1
Caspase-11
E coli
Gram-negative bacteria
Gram-positive bacteria
Immunology
Immunotherapy
Infections
Infectious Diseases
Inflammasomes
Interleukin-1beta
Ligands
Lipopolysaccharides
mRNA
News & Views
news-and-views
NLR Family, Pyrin Domain-Containing 3 Protein
Virulence
Title Dual ligand engagement for noncanonical inflammasome activation
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