Dual ligand engagement for noncanonical inflammasome activation

The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.

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Bibliographic Details
Published inNature immunology Vol. 23; no. 5; pp. 651 - 653
Main Authors Yang, Zhang-Hua, Han, Jiahuai
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.05.2022
Nature Publishing Group
Subjects
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Acidification
Bacteria
Bacterial infections
Biomedical and Life Sciences
Biomedicine
Cancer
Caspase 1
Caspase-11
E coli
Gram-negative bacteria
Gram-positive bacteria
Immunology
Immunotherapy
Infections
Infectious Diseases
Inflammasomes
Interleukin-1beta
Ligands
Lipopolysaccharides
mRNA
News & Views
news-and-views
NLR Family, Pyrin Domain-Containing 3 Protein
Virulence
Online AccessGet full text

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Summary:The activation of the noncanonical NLRP3 inflammasome can be elicited by the interaction and interdependent activation of caspase-11 and NLRP3 that follows coincident cytosolic detection of lipopolysaccharide and bacterial mRNA from live Gram-negative bacteria.
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ISSN:1529-2908
1529-2916
1529-2916
DOI:10.1038/s41590-022-01188-0