An IFNγ-dependent immune–endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response

• Published in: Nature immunology Vol. 25; no. 6; pp. 981 - 993
• Main Authors: Šestan, Marko, Mikašinović, Sanja, Benić, Ante, Wueest, Stephan, Dimitropoulos, Christoforos, Mladenić, Karlo, Krapić, Mia, Hiršl, Lea, Glantzspiegel, Yossef, Rasteiro, Ana, Aliseychik, Maria, Cekinović Grbeša, Đurđica, Turk Wensveen, Tamara, Babić, Marina, Gat-Viks, Irit, Veiga-Fernandes, Henrique, Konrad, Daniel, Wensveen, Felix M., Polić, Bojan
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2024; Nature Publishing Group
• Subjects: 631/250/127/1212; 631/250/254; Animals; Antiviral drugs; Beta cells; Biomedical and Life Sciences; Biomedicine; Blood; Blood glucose; Blood Glucose - metabolism; Diabetes mellitus; Glucose; Humans; Hyperglycemia; Hyperglycemia - immunology; Hyperinsulinemia; Immune response; Immune system; Immunity, Innate; Immunology; Infections; Infectious Diseases; Insulin - immunology; Insulin - metabolism; Insulin secretion; Insulin-Secreting Cells - immunology; Insulin-Secreting Cells - metabolism; Interferon regulatory factor 3; Interferon Regulatory Factor-3 - metabolism; Interferon-gamma - immunology; Interferon-gamma - metabolism; Liver - immunology; Liver - metabolism; Liver - virology; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B - metabolism; NF-κB protein; Pancreas; Pathogens; Signal Transduction - immunology; Viral infections; γ-Interferon
• ISSN: 1529-2908; 1529-2916; 1529-2916
• DOI: 10.1038/s41590-024-01848-3

Viral infection makes us feel sick as the immune system alters systemic metabolism to better fight the pathogen. The extent of these changes is relative to the severity of disease. Whether blood glucose is subject to infection-induced modulation is mostly unknown. Here we show that strong, nonlethal infection restricts systemic glucose availability, which promotes the antiviral type I interferon (IFN-I) response. Following viral infection, we find that IFNγ produced by γδ T cells stimulates pancreatic β cells to increase glucose-induced insulin release. Subsequently, hyperinsulinemia lessens hepatic glucose output. Glucose restriction enhances IFN-I production by curtailing lactate-mediated inhibition of IRF3 and NF-κB signaling. Induced hyperglycemia constrained IFN-I production and increased mortality upon infection. Our findings identify glucose restriction as a physiological mechanism to bring the body into a heightened state of responsiveness to viral pathogens. This immune–endocrine circuit is disrupted in hyperglycemia, possibly explaining why patients with diabetes are more susceptible to viral infection. Sestan et al. find a conserved mechanism during systemic viral infection in which γδ T cells produce IFNγ to increase pancreatic insulin secretion, lowering blood glucose and then enhancing type I interferon-mediated protection against viral infection.